A new series of thiazolyl-pyrazoline derivatives (4a–d, 5a–d 6a, b, 7a–d, 8a, b, and 10a, b)
have been designed and synthesized through the combination of thiazole and pyrazoline …

An active approach for the preparation of a series of novel 3-[2ʹ-(4ʹ-aryl-1, 3-thiazol-2ʹ-yl)
hydrazono] indoline-2-one derivatives (4) has been executed by a one-pot multicomponent …

The Hydrophobicity mean the compounds which insoluble in water ie, hate the water (not
love the water). May be these compounds are lipid soluble, but not actually. This means …

Inflammation is central to numerous diseases, highlighting the need for new anti-
inflammatory agents. This study explores the potential of novel spirofused indoline …

Breast cancer, an epithelial malignant tumor that occurs in the terminal ducts of the breast,
represents the most prevalent malignancy in women, with over 2 million new diagnoses …

Vascular endothelial growth factor (VEGF) is a crucial key factor in breast tumorigenesis.
VEGF plays an important role in angiogenesis, tumor proliferation, and metastasis. Herein …

Organic halogen compounds are cornerstones of applied chemical sciences. Halogen
substitution is a smart molecular design strategy adopted to influence reactivity, membrane …

Vascular endothelial growth factor is an angiogenic that promotes the development and
metastasis of tumors (VEGF). The epidermal growth factor receptor, or EGFR, controls the …

Background Thiazole derivatives are gaining prominence in cancer research due to their
potent anti-cancer effects and multifaceted biological activities. In leukemia research, these …

Enzyme inhibition is an important process in the mode of action of many drugs used in the
treatment of various diseases. Antibiotics, anti-hypertensive agents, anti-hyperlipidaemic …