Understanding the principles of information processing in neural circuits requires systematic
characterization of the participating cell types and their connections, and the ability to …

Within the last 400 million years, insects have radiated into at least a million species,
accounting for more than half of all known living organisms: they are the most successful …

A wide variety of biological experiments rely on the ability to express an exogenous gene in
a transgenic animal at a defined level and in a spatially and temporally controlled pattern …

Internal nutrient sensors play important roles in feeding behavior, yet their molecular
structure and mechanism of action are poorly understood. Using Ca 2+ imaging and …

Research in the fruit fly Drosophila melanogaster has led to insights in neural development,
axon guidance, ion channel function, synaptic transmission, learning and memory, diurnal …

Selective genetic manipulation of neuronal function in vivo requires techniques for targeting
gene expression to specific cells. Existing systems accomplish this using the promoters of …

The mushroom body is required for a variety of behaviors of Drosophila melanogaster.
Different types of intrinsic and extrinsic mushroom body neurons might underlie its functional …

Tissue-specific gene expression using the upstream activating sequence (UAS)–GAL4
binary system has facilitated genetic dissection of many biological processes in Drosophila …

Intraneuronal tau aggregations are distinctive pathological features of Parkinson's disease
(PD) with autosomal-dominant mutations in leucine-rich repeat kinase 2 (LRRK2). The most …

The yeast Gal4/UAS transcriptional activation system is a powerful tool for regulating gene
expression in Drosophila and has been increasing in popularity for developmental studies in …