The toxicity of silica nanoparticles to the immune system

L Chen, J Liu, Y Zhang, G Zhang, Y Kang, A Chen… - …, 2018 - Taylor & Francis
Silicon-based materials and their oxides are widely used in drug delivery, dietary
supplements, implants and dental fillers. Silica nanoparticles (SiNPs) interact with …

Interactions of nanomaterials with ion channels and related mechanisms

S Yin, J Liu, Y Kang, Y Lin, D Li… - British journal of …, 2019 - Wiley Online Library
The pharmacological potential of nanotechnology, especially in drug delivery and
bioengineering, has developed rapidly in recent decades. Ion channels, which are easily …

Silica nanoparticles induce lung inflammation in mice via ROS/PARP/TRPM2 signaling-mediated lysosome impairment and autophagy dysfunction

M Wang, J Li, S Dong, X Cai, A Simaiti, X Yang… - Particle and Fibre …, 2020 - Springer
Background Wide applications of nanoparticles (NPs) have raised increasing concerns
about safety to humans. Oxidative stress and inflammation are extensively investigated as …

The effect of silica nanoparticles on human corneal epithelial cells

JH Park, H Jeong, J Hong, M Chang, M Kim… - Scientific reports, 2016 - nature.com
Ocular drug delivery is an interesting field in current research. Silica nanoparticles (SiNPs)
are promising drug carriers for ophthalmic drug delivery. However, little is known about the …

Predisposition to Alzheimer's and age-related brain pathologies by PM2. 5 exposure: Perspective on the roles of oxidative stress and TRPM2 channel

L Wang, LY Wei, R Ding, Y Feng, D Li, C Li… - Frontiers in …, 2020 - frontiersin.org
Accumulating epidemiological evidence supports that chronic exposure to ambient fine
particular matters of< 2.5 μm (PM2. 5) predisposes both children and adults to Alzheimer's …

Amorphous nanosilica induced toxicity, inflammation and innate immune responses: A critical review

N Sharma, S Jha - Toxicology, 2020 - Elsevier
Nanoparticles are promising bioengineering platforms facilitating various consumer product
formulations, including packaged food, electrical, biosensor and biomedical tools. The …

Trp channels as cellular targets of particulate matter

A Milici, K Talavera - International Journal of Molecular Sciences, 2021 - mdpi.com
Particulate matter (PM) is constituted by particles with sizes in the nanometer to micrometer
scales. PM can be generated from natural sources such as sandstorms and wildfires, and …

Dual stimuli-responsive multifunctional silicon nanocarriers for specifically targeting mitochondria in human cancer cells

VA Tran, GV Vo, MA Tan, JS Park, SSA An, SW Lee - Pharmaceutics, 2022 - mdpi.com
Specific targeting, selective stimuli-responsiveness, and controlled release of anticancer
agents are requested for high therapeutic efficiency with a minimal adverse effect. Herein …

Design, synthesis and biological activities of 2, 3-dihydroquinazolin-4 (1H)-one derivatives as TRPM2 inhibitors

H Zhang, H Liu, X Luo, Y Wang, Y Liu, H Jin… - European Journal of …, 2018 - Elsevier
Transient receptor potential melastatin 2 (TRPM2), a Ca 2+-permeable cationic channel,
plays critical roles in insulin release, cytokine production, body temperature regulation and …

Ratiometric fluorescent quantification of the size-dependent cellular toxicity of silica nanoparticles

X Wan, X Zhang, W Pan, B Liu, L Yu, H Wang… - Analytical …, 2019 - ACS Publications
Nanoscale particles are ubiquitous in the atmosphere, and the widespread use of
nanoparticles may increase the risks of organ damage. Therefore, it is of great significance …