Large scale human genetic studies have shown that loss of function (LoF) mutations in
MYT1L are implicated in neurodevelopmental disorders (NDDs). Here, we provide an …

Pathogenic variants of the myelin transcription factor-1 like (MYT1L) gene include
heterozygous missense, truncating variants and 2p25. 3 microdeletions and cause a …

Human genetics have defined a new neurodevelopmental syndrome caused by loss-of-
function mutations in MYT1L, a transcription factor known for enabling fibroblast-to-neuron …

MYT1L is an autism spectrum disorder (ASD)-associated transcription factor that is
expressed in virtually all neurons throughout life. How MYT1L mutations cause neurological …

Mutations reducing the function of MYT1L, a neuron-specific transcription factor, are
associated with a syndromic neurodevelopmental disorder. MYT1L is used as a pro-neural …

Myelin transcription factor 1 like (Myt1l), a zinc-finger transcription factor, promotes neuronal
differentiation and is implicated in autism spectrum disorder (ASD) and intellectual disability …

Sensory hair cells are prone to apoptosis caused by various drugs including aminoglycoside
antibiotics. In mammals, this vulnerability results in permanent hearing loss because lost …

Gliomas portray a large and heterogeneous group of CNS tumors, encompassing a wide
range of low-to high-grade tumors, as defined by histological and molecular characteristics …

Abstract Motivation Percent Spliced-In (PSI) values are commonly used to report alternative
pre-mRNA splicing (AS) changes. Previous PSI-detection tools were limited to specific AS …

In vitro studies indicate the neurodevelopmental disorder gene myelin transcription factor 1-
like (MYT1L) suppresses non-neuronal lineage genes during fibroblast-to-neuron direct …