Emerging roles of circular RNAs in osteoporosis

W Chen, B Zhang, X Chang - Journal of Cellular and Molecular …, 2021 - Wiley Online Library
Osteoporosis is one bone disease characterized with skeletal impairment, bone strength
reduced and fracture risk enhanced. The regulation processes of bone metabolism are …

Adipocyte-and monocyte-mediated vicious circle of inflammation and obesity (review of cellular and molecular mechanisms)

N Todosenko, O Khaziakhmatova… - International Journal of …, 2023 - mdpi.com
Monocytes play a key role in the development of metabolic syndrome, and especially
obesity. Given the complex features of their development from progenitor cells, whose …

Bone marrow adipose tissue in metabolic health

G Pachón-Peña, MA Bredella - Trends in Endocrinology & Metabolism, 2022 - cell.com
Recent studies have highlighted the role of bone marrow adipose tissue (BMAT) as a
regulator of skeletal homeostasis and energy metabolism. While long considered an inert …

Bone marrow adipocytes: a critical player in the bone marrow microenvironment

L Wang, H Zhang, S Wang, X Chen… - Frontiers in Cell and …, 2021 - frontiersin.org
Recognized for nearly 100 years, bone marrow adipocytes (BMAs) form bone marrow
niches that contain hematopoietic and bone cells, the roles of which have long been …

Osteocytes and weightlessness

D Iandolo, M Strigini, A Guignandon, L Vico - Current osteoporosis reports, 2021 - Springer
Abstract Purpose of Review Osteocytes are considered to be the cells responsible for
mastering the remodeling process that follows the exposure to unloading conditions. Given …

Bone marrow adiposity during pathologic bone loss: molecular mechanisms underlying the cellular events

J Li, L Lu, Y Liu, X Yu - Journal of Molecular Medicine, 2022 - Springer
Bone marrow (BM) is a heterogeneous niche where bone marrow stromal cells (BMSCs),
osteoblasts, osteoclasts, adipocytes, hematopoietic cells, and immune cells coexist. The …

Fatty infiltration in the musculoskeletal system: Pathological mechanisms and clinical implications

Y Zhu, Y Hu, Y Pan, M Li, Y Niu, T Zhang… - Frontiers in …, 2024 - frontiersin.org
Fatty infiltration denotes the anomalous accrual of adipocytes in non-adipose tissue, thereby
generating toxic substances with the capacity to impede the ordinary physiological functions …

Obesity, diabetes and risk of bone fragility: How BMAT behavior is affected by metabolic disturbances and its influence on bone health

GC Guimarães, JBC Coelho, JGO Silva… - Osteoporosis …, 2024 - Springer
Purpose Osteoporosis is a metabolic bone disease characterized by decreased bone
strength and mass, which predisposes patients to fractures and is associated with high …

Common regulators of lipid metabolism and bone marrow adiposity in postmenopausal women

DY Kim, SH Ko - Pharmaceuticals, 2023 - mdpi.com
A variety of metabolic disorders are associated with a decrease in estradiol (E2) during
natural or surgical menopause. Postmenopausal women are prone to excessive fat …

Bone Marrow Adipocytes as Novel Regulators of Metabolic Homeostasis: Clinical Consequences of Bone Marrow Adiposity

H Liu, L Liu, CJ Rosen - Current Obesity Reports, 2025 - Springer
This review provides an up-to-date synthesis of current knowledge on bone marrow
adipocytes, emphasizing the relationships between bone marrow adipogenesis and factors …