The role of enhancers in cancer
Enhancer elements function as the logic gates of the genetic regulatory circuitry. One of their
most important functions is the integration of extracellular signals with intracellular cell fate …
most important functions is the integration of extracellular signals with intracellular cell fate …
Beyond GWASs: illuminating the dark road from association to function
Genome-wide association studies (GWASs) have enabled the discovery of common genetic
variation contributing to normal and pathological traits and clinical drug responses, but …
variation contributing to normal and pathological traits and clinical drug responses, but …
HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants
The resolution of genome-wide association studies (GWAS) is limited by the linkage
disequilibrium (LD) structure of the population being studied. Selecting the most likely …
disequilibrium (LD) structure of the population being studied. Selecting the most likely …
CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer
The functional roles of SNPs within the 8q24 gene desert in the cancer phenotype are not
yet well understood. Here, we report that CCAT2, a novel long noncoding RNA transcript …
yet well understood. Here, we report that CCAT2, a novel long noncoding RNA transcript …
Junk DNA and the long non-coding RNA twist in cancer genetics
The central dogma of molecular biology states that the flow of genetic information moves
from DNA to RNA to protein. However, in the last decade this dogma has been challenged …
from DNA to RNA to protein. However, in the last decade this dogma has been challenged …
From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis
S Dhamija, S Diederichs - International journal of cancer, 2016 - Wiley Online Library
Metastasis is a multistep process that involves the dissemination of cells from the primary
tumor and colonization of distant secondary organs. Epithelial cells at the invasive front of a …
tumor and colonization of distant secondary organs. Epithelial cells at the invasive front of a …
Progress and promise of genome-wide association studies for human complex trait genetics
Enormous progress in mapping complex traits in humans has been made in the last 5 yr.
There has been early success for prevalent diseases with complex phenotypes. These …
There has been early success for prevalent diseases with complex phenotypes. These …
Common genetic variants on 5p14. 1 associate with autism spectrum disorders
K Wang, H Zhang, D Ma, M Bucan, JT Glessner… - Nature, 2009 - nature.com
Autism spectrum disorders (ASDs) represent a group of childhood neurodevelopmental and
neuropsychiatric disorders characterized by deficits in verbal communication, impairment of …
neuropsychiatric disorders characterized by deficits in verbal communication, impairment of …
The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer
MM Pomerantz, N Ahmadiyeh, LI Jia, P Herman… - Nature …, 2009 - nature.com
An inherited variant on chromosome 8q24, rs6983267, is significantly associated with
cancer pathogenesis. We present evidence that the region harboring this variant is a …
cancer pathogenesis. We present evidence that the region harboring this variant is a …
Long non-coding RNA PVT1 interacts with MYC and its downstream molecules to synergistically promote tumorigenesis
K Jin, S Wang, Y Zhang, M Xia, Y Mo, X Li, G Li… - Cellular and Molecular …, 2019 - Springer
Numerous studies have shown that non-coding RNAs play crucial roles in the development
and progression of various tumor cells. Plasmacytoma variant translocation 1 (PVT1) mainly …
and progression of various tumor cells. Plasmacytoma variant translocation 1 (PVT1) mainly …