Tumor associated macrophages (TAMs) are the most frequent immune cells within tumor
microenvironment (TME). There is growing evidence that TAMs are involved in tumor …

Tumor-associated macrophages (TAMs), representing most of the leukocyte population in
solid tumors, demonstrate great phenotypic heterogeneity and diverse functional capabilities …

Deleterious inflammation is a primary feature of breast cancer. Accumulating evidence
demonstrates that macrophages, the most abundant leukocyte population in mammary …

Purpose Tumor associated macrophages (TAMs) are considered with the capacity to have
both negative and positive effects on tumor growth. The prognostic value of TAM for survival …

Tumor angiogenesis is an essential process for supplying rapidly growing malignant tissues
with essential nutrients and oxygen. An angiogenic switch allows tumor cells to survive and …

The CCL2 chemokine mediates monocyte egress from bone marrow and recruitment into
inflamed tissues through interaction with the CCR2 chemokine receptor, and its expression …

Chemokines constitute a family of chemoattractant cytokines and are subdivided into four
families on the basis of the number and spacing of the conserved cysteine residues in the N …

The use of various transgenic mouse models and analysis of human tumour biopsies has
shown that bone marrow-derived myeloid cells, such as macrophages, neutrophils …

Blood vessels promote tumour growth, and both blood and lymphatic vessels facilitate
tumour metastasis by serving as conduits for the transport of tumour cells to new sites …

Innate and adaptive immune cells patrol and survey throughout the human body and
sometimes reside in the tumor microenvironment (TME) with a variety of cell types and …