Due to its dynamic nature, the evolution of cancer cell-extracellular matrix (ECM) crosstalk,
critically affecting metastasis and treatment resistance, remains elusive. Our results show …

Extracellular vesicles (EVs) are membranous structures derived from the endosomal system
or generated by plasma membrane shedding. Due to their composition of DNA, RNA …

Small RNAs (sRNAs) are important short-length molecules with regulatory functions
essential for plant development and plasticity. High-throughput sequencing of total sRNA …

Mitochondrial DNA (mtDNA) mutagenesis and nuclear DNA repair defects are considered
cellular mechanisms of ageing. mtDNA mutator mice with increased mtDNA mutagenesis …

Copy-number alterations (CNAs) are a hallmark of cancer and can regulate cancer cell
states via altered gene expression values. Herein, we have developed a copy-number …

Cancer is the most complex genetic disease known, with mutations implicated in more than
250 genes. However, it is still elusive which specific mutations found in human patients lead …

Motivation A major challenge in analyzing cancer patient transcriptomes is that the tumors
are inherently heterogeneous and evolving. We analyzed 214 bulk RNA samples of a …

Anduril is an analysis and integration framework that facilitates the design, use,
parallelization and reproducibility of bioinformatics workflows. Anduril has been upgraded to …

Poor chemotherapy response remains a major treatment challenge for high‐grade serous
ovarian cancer (HGSC). Cancer stem cells are the major contributors to relapse and …

Diffuse large B-cell lymphoma (DLBCL) is a biologically and clinically heterogeneous
disease whose personalized clinical management requires robust molecular stratification …