Alzheimer's disease (AD) is considered a polygenic disorder. This view is clouded, however,
by lingering uncertainty over how to treat the quasi" monogenic" role of apolipoprotein E …

Objective: To examine the role of butyrylcholinesterase (BuChE) in cholinergic signaling and
neurologic conditions, such as Alzheimer's disease (AD). The rationale for inhibiting …

Background The study aimed to validate previously discovered plasma biomarkers
associated with AD, using a design based on imaging measures as surrogate for disease …

Deposition of amyloid-β (Aβ) in the cerebral cortex is thought to be a pivotal event in
Alzheimer's disease (AD) pathogenesis with a significant genetic contribution. Molecular …

Abstract Acetylcholinesterase (AChE, EC 3.1. 1.7) and butyrylcholinesterase (BChE, EC 3.1.
1.8) are related enzymes found across the animal kingdom. The critical role of …

Objectives Apolipoproteins have recently been implicated in the etiology of Alzheimer's
disease (AD). In particular, Apolipoprotein J (ApoJ or clusterin) has been proposed as a …

Alzheimer's disease (AD) is a complex and progressive disease, which affects millions of
people around the world. Despite the many efforts over the years to find efficient …

The accumulation of β-amyloid in the brain is an early event in Alzheimer's disease. This
study presents the first patient with Alzheimer's disease who underwent positron emission …

Herein, we report a first example of a rapid and easy to use paper-based printed sensor
embedded in a 3D printing device to measure the butyrylcholinesterase activity in serum …

While acetylcholinesterase (EC 3.1. 1.7) has a clearly defined role in neurotransmission, the
functions of its sister enzyme butyrylcholinesterase (EC 3.1. 1.8) are more obscure …