Learning and memory are fundamental but highly complex functions of the brain. They rely
on multiple mechanisms including the processing of sensory information, memory formation …

Alzheimer's disease poses a significant global health challenge owing to the progressive
cognitive decline of patients and absence of curative treatments. The current therapeutic …

The unfolded protein response (UPR) is rapidly gaining momentum as a therapeutic target
for protein misfolding neurodegenerative diseases, in which its overactivation results in …

The astrocyte-neuron lactate shuttle (ANLS) model posits that astrocyte-generated lactate is
transported to neurons to fuel memory processes. However, neurons express high levels of …

Nasopharyngeal carcinoma (NPC) is the most common cancer originating in nasopharynx.
Metabolic reprogramming plays a critical role in tumor progression. Exploring mechanisms …

Alzheimer's disease (AD) is a degenerative disease of the central nervous system, the most
common type of dementia in old age, which causes progressive loss of cognitive functions …

Astrocytes, which actively participate in cognitive processes, have a complex spongiform
morphology, highlighted by extensive ramified fine processes that closely enwrap the pre …

Ischemic stroke, a leading cause of disability and mortality worldwide, is characterized by
the sudden loss of blood flow in specific area of the brain. Intravenous thrombolysis with …

Abstract Fibroblast growth factor 21 (FGF21) is one endogenous metabolic molecule that
functions as a regulator in glucose and lipid homeostasis. However, the effect of FGF21 on L …

Astrocytes are critical for maintaining neuronal activity. Activation of astrocytes, occurs within
minutes from ischemic stroke onset due to ischemic causes and subsequent inflammatory …