The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

SF3B1 splicing factor mutations are near-universally found in myelodysplastic syndromes
(MDS) with ring sideroblasts (RS), a clonal hematopoietic disorder characterized by …

The sideroblastic anemias are a heterogeneous group of inherited and acquired disorders
characterized by anemia and the presence of ring sideroblasts in the bone marrow. Ring …

The most widely appreciated role of DNA is to encode protein, yet the exact portion of the
human genome that is translated remains to be ascertained. We previously developed …

Mutations in splicing factors (SF) are the predominant class of mutations in myelodysplastic
syndrome (MDS), but convergent downstream disease drivers remain elusive. To identify …

Cancer-associated mutations in the spliceosome gene SF3B1 create a neomorphic protein
that produces aberrant mRNA splicing in hundreds of genes, but the ensuing biologic and …

Acquired sideroblastic anemia, characterized by bone marrow ring sideroblasts (RS), is
predominantly associated with myelodysplastic syndrome (MDS). Although somatic …

Abnormal nuclear morphology is a hallmark of malignant cells widely used in cancer
diagnosis. Pelger-Huët anomaly (PHA) is a common abnormality of neutrophil nuclear …

Many inherited bone marrow failure syndromes (IBMFSs) present a high risk of
transformation to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) …

The reprogramming of human acute myeloid leukemia (AML) cells into induced pluripotent
stem cell (iPSC) lines could provide new faithful genetic models of AML, but is currently …