Alternative splicing is a widespread process contributing to structural transcript variation and
proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both …

Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …

The immense majority of genes are alternatively spliced and there are many isoforms
specifically associated with cancer progression and metastasis. The splicing pattern of …

Gastric cancer remains one of the most common cancers worldwide and one of the leading
cause for cancer-related deaths. Gastric adenocarcinoma is a multifactorial disease that is …

Zinc is a trace element nutrient that is essential for life. This mineral serves as a cofactor for
enzymes that are involved in critical biochemical processes and it plays many structural …

Abstract Serine/Arginine Splicing Factor 1 (SRSF1) is the archetype member of the SR
protein family of splicing regulators. Since its discovery over two decades ago, SRSF1 has …

Abstract Background The Cancer Genome Atlas (TCGA) offers a multilayered view of
genomics and epigenomics data of many human cancer types. However, the retrieval of …

Zinc, iron, and manganese are essential trace elements that serve as catalytic or structural
components of larger molecules that are indispensable for life. The three metal ions possess …

It is well established that lncRNAs are aberrantly expressed in cancer where they have been
shown to act as oncogenes or tumor suppressors. RNA profiling of 314 colorectal …

The determination of the alternative splicing isoforms expressed in cancer is fundamental for
the development of tumor-specific molecular targets for prognosis and therapy, but it is …