WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

Macrophages are often viewed through the lens of their core functions, but recent
transcriptomic studies reveal them to be largely distinct across tissue types. While these …

Aims Atherosclerosis, the leading cause of cardiovascular diseases, is driven by high blood
cholesterol levels and chronic inflammation. Low-density lipoprotein receptors (LDLR) play …

The Wnt signalling pathways are composed of a highly conserved cascade of events that
govern cell differentiation, apoptosis and cell orientation. Three major and distinct Wnt …

The effect of glucosylceramide (GlcCer) reprogramming on liver cancer metastasis remains
poorly understood. In this study, we demonstrated that the protein expression of GBA1 …

Triple negative breast cancer is a clinically challenging subtype due to lack of biomarker for
rational targeted therapy. Lipid rafts are cholesterol enriched rigid platforms, which …

Wnt signaling encompasses multiple and complex signaling cascades and is involved in
many developmental processes such as tissue patterning, cell fate specification, and control …

Previous studies by us and others demonstrated that activation of Wnt/β-catenin signaling
plays a pathogenic role in chronic kidney diseases (CKD). Wnt co-receptor LRP5 variants …

Aims There is little information on the regulation of cholesterol homeostasis in the brain.
Whether cholesterol crosses the blood–brain barrier is under investigation, but the present …

Aims Myocardial infarction induces myocardial injury and tissue damage. During myocardial
infarction strong cellular response is initiated to salvage the damaged tissues. This response …