Cellular functions of eukaryotic RNA helicases and their links to human diseases
KE Bohnsack, S Yi, S Venus, E Jankowsky… - … Reviews Molecular Cell …, 2023 - nature.com
RNA helicases are highly conserved proteins that use nucleoside triphosphates to bind or
remodel RNA, RNA–protein complexes or both. RNA helicases are classified into the DEAD …
remodel RNA, RNA–protein complexes or both. RNA helicases are classified into the DEAD …
The proteins of mRNA modification: writers, readers, and erasers
MN Flamand, M Tegowski… - Annual review of …, 2023 - annualreviews.org
Over the past decade, mRNA modifications have emerged as important regulators of gene
expression control in cells. Fueled in large part by the development of tools for detecting …
expression control in cells. Fueled in large part by the development of tools for detecting …
The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities
RNA modifications have recently emerged as critical posttranscriptional regulators of gene
expression programmes. Significant advances have been made in understanding the …
expression programmes. Significant advances have been made in understanding the …
Role of RNA modifications in cancer
I Barbieri, T Kouzarides - Nature Reviews Cancer, 2020 - nature.com
Specific chemical modifications of biological molecules are an efficient way of regulating
molecular function, and a plethora of downstream signalling pathways are influenced by the …
molecular function, and a plethora of downstream signalling pathways are influenced by the …
m6A modification in coding and non-coding RNAs: roles and therapeutic implications in cancer
N 6-Methyladenosine (m 6 A) RNA modification has emerged in recent years as a new layer
of regulatory mechanism controlling gene expression in eukaryotes. As a reversible …
of regulatory mechanism controlling gene expression in eukaryotes. As a reversible …
FTO in cancer: functions, molecular mechanisms, and therapeutic implications
N 6-methyladenosine (m 6 A) is the most abundant internal modification in mRNA that
affects RNA processing, stability, and translation. Discovered as the first RNA m 6 A …
affects RNA processing, stability, and translation. Discovered as the first RNA m 6 A …
The Critical Role of RNA m6A Methylation in Cancer
Since the identification of the first RNA demethylase and the establishment of methylated
RNA immunoprecipitation-sequencing methodology 6 to 7 years ago, RNA methylation has …
RNA immunoprecipitation-sequencing methodology 6 to 7 years ago, RNA methylation has …
Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism
Abstract N 6-methyladenosine (m6A) is a chemical modification present in multiple RNA
species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze …
species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze …
The Emerging Roles of RNA m6A Methylation and Demethylation as Critical Regulators of Tumorigenesis, Drug Sensitivity, and Resistance
Q Lan, PY Liu, JL Bell, JY Wang, S Hüttelmaier… - Cancer research, 2021 - AACR
Abstract RNA N6-methyladenosine (m6A) modification occurs in approximately 25% of
mRNAs at the transcriptome-wide level. RNA m6A is regulated by the RNA m6A …
mRNAs at the transcriptome-wide level. RNA m6A is regulated by the RNA m6A …
m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2
Dynamic mRNA modification in the form of N 6-methyladenosine (m6A) adds considerable
richness and sophistication to gene regulation. The m6A mark is asymmetrically distributed …
richness and sophistication to gene regulation. The m6A mark is asymmetrically distributed …