Mycobacterium tuberculosis, which is the aetiological agent of tuberculosis, owes much of its
success as a pathogen to its unique cell wall and unusual mechanism of growth, which …

Similar to its eukaryotic counterpart, the prokaryotic cytoskeleton is essential for the
structural and mechanical properties of bacterial cells. The essential protein FtsZ is a central …

We introduce a nonintrusive method exploiting single-cell variability after cell division to
validate protein localization. We found that Clp proteases, widely reported to form …

For centuries, natural products (NPs) have served as powerful therapeutics against a variety
of human ailments. Nowadays, they still represent invaluable resources for the treatment of …

Bacillus subtilis is the best described member of the Gram positive bacteria. It is a typical rod
shaped bacterium and grows by elongation in its long axis, before dividing at mid cell to …

Proteases have been successfully targeted for the treatment of several diseases, including
hypertension, type 2 diabetes, multiple myeloma, HIV and hepatitis C virus infections. Given …

The last three decades have witnessed an explosion of discoveries about the mechanistic
details of binary fission in model bacteria such as Escherichia coli, Bacillus subtilis, and …

Mycobacteria are members of the actinomycetes that grow by tip extension and lack
apparent homologues of the known cell division regulators found in other rod-shaped …

β-lactam antibiotics interfere with cross-linking of the bacterial cell wall, but the killing
mechanism of this important class of antibiotics is not fully understood. Serendipitously we …

Mycobacteria are among the clinically most important pathogens, but still not much is known
about the mechanisms of their cell cycle control. Previous studies suggested that the genes …