Ligand-targeted delivery of photosensitizers for cancer treatment

P Gierlich, AI Mata, C Donohoe, RMM Brito, MO Senge… - Molecules, 2020 - mdpi.com
Photodynamic therapy (PDT) is a promising cancer treatment which involves a
photosensitizer (PS), light at a specific wavelength for PS activation and oxygen, which …

Progress and trends of photodynamic therapy: From traditional photosensitizers to AIE-based photosensitizers

S Wang, X Wang, L Yu, M Sun - Photodiagnosis and Photodynamic …, 2021 - Elsevier
Photodynamic therapy (PDT) is an established clinical treatment technology which utilizes
excitation light of a specific wavelength to activate photosensitizers (PSs) to generate …

An unexpected strategy to alleviate hypoxia limitation of photodynamic therapy by biotinylation of photosensitizers

J An, S Tang, G Hong, W Chen, M Chen, J Song… - Nature …, 2022 - nature.com
The most common working mechanism of photodynamic therapy is based on high-toxicity
singlet oxygen, which is called Type II photodynamic therapy. But it is highly dependent on …

Chlorin e6-biotin conjugates for tumor-targeting photodynamic therapy

W Liu, X Ma, Y Jin, J Zhang, Y Li, Y Tang, Y Song… - Molecules, 2021 - mdpi.com
To improve the tumor-targeting efficacy of photodynamic therapy, biotin was conjugated with
chlorin e6 to develop a new tumor-targeting photosensitizer, Ce6-biotin. The Ce6-biotin had …

Phthalocyanine and its formulations: a promising photosensitizer for cervical cancer phototherapy

LR Carobeli, LEF Meirelles, GMZF Damke, E Damke… - Pharmaceutics, 2021 - mdpi.com
Cervical cancer is one of the most common causes of cancer-related deaths in women
worldwide. Despite advances in current therapies, women with advanced or recurrent …

Novel triazole containing zinc (II) phthalocyanine Schiff bases: Determination of photophysical and photochemical properties for photodynamic cancer therapy

K Harmandar, MF Saglam, IF Sengul, G Ekineker… - Inorganica Chimica …, 2021 - Elsevier
A simple and efficient synthesis of novel zinc (II) phthalocyanines bearing triazole moieties
was described. The synthetic approach for preparation of the phthalocyanines 1 and 13 was …

[HTML][HTML] Sonodynamic Therapy for HER2+ Breast Cancer with Iodinated Heptamethine Cyanine–Trastuzumab Conjugate

D Kobzev, O Semenova, S Aviel-Ronen… - International Journal of …, 2024 - mdpi.com
The first example of sonodynamic therapy (SDT) with a cyanine dye–antibody conjugate is
reported. The aim of this study was to evaluate the sonodynamic efficacy of a trastuzumab …

Low-dose near-infrared light-activated mitochondria-targeting photosensitizers for PDT cancer therapy

W Wu Klingler, N Giger, L Schneider, V Babu… - International Journal of …, 2022 - mdpi.com
Phthalocyanines (Pcs) are promising candidates for photodynamic therapy (PDT) due to
their absorption in the phototherapeutic window. However, the highly aromatic Pc core leads …

Synthesis and photodiode properties of chalcone substituted metallo-phthalocyanine

M Demirol, L Sirka, E Çalışkan, F Biryan… - Journal of Molecular …, 2020 - Elsevier
In this study, we aimed to investigate the photodiode properties of the chalcone substituted-
phthalocyanine complex due to the important physical properties of the phthalocyanine and …

Development of a small molecule-based two-photon photosensitizer for targeting cancer cells

DJ Lee, Y Cao, V Juvekar, CK Noh, SJ Shin… - Journal of Materials …, 2024 - pubs.rsc.org
Photodynamic therapy (PDT) employing two-photon (TP) excitation is increasingly
recognized to induce cell damage selectively in targeted areas, underscoring the …