Box–Behnken design of thermo-responsive nano-liposomes loaded with a platinum (IV) anticancer complex: evaluation of cytotoxicity and apoptotic pathways in triple …

NK Sedky, M Braoudaki, NK Mahdy, K Amin… - Nanoscale …, 2023 - pubs.rsc.org
Herein, thermo-responsive liposomes (TLs) loaded with Asp (Asp/TLs) were produced by
self-assembling DPPC, DSPE-PEG2000, and cholesterol. The preparation variables were …

Role and regulation of proapoptotic Bax in oral squamous cell carcinoma and drug resistance

M Alam, T Kashyap, P Mishra, AK Panda… - Head & …, 2019 - Wiley Online Library
Background Bax, a proapoptotic protein but its regulation during oral cancer progression
and resistance remains elusive. Methods A total of 127 samples including adjacent normal …

High‐resolution analysis of the conformational transition of pro‐apoptotic Bak at the lipid membrane

LE Sperl, F Rührnößl, A Schiller, M Haslbeck… - The EMBO …, 2021 - embopress.org
Permeabilization of the outer mitochondrial membrane by pore‐forming Bcl2 proteins is a
crucial step for the induction of apoptosis. Despite a large set of data suggesting global …

Analysis of the Polymorphisms and Expression Levels of the BCL2, BAX and c-MYC Genes in Patients with Ovarian Cancer

PJ Olbromski, A Bogacz, M Bukowska… - International Journal of …, 2023 - mdpi.com
Ovarian cancer (OC) is one of the biggest problems in gynecological oncology and is one of
the most lethal cancers in women worldwide. Most patients with OC are diagnosed at an …

Mycobacterium tuberculosis PE_PGRS1 promotes mycobacteria intracellular survival via reducing the concentration of intracellular free Ca2+ and suppressing …

X Yu, Y Huang, Y Li, T Li, S Yan, X Ai, X Lv, L Fan… - Molecular …, 2023 - Elsevier
Mycobacterium tuberculosis (M. tuberculosis) is the causative agent of tuberculosis (TB).
And the PE_PGRS family members of M. tuberculosis are closely associated with virulence …

BAX and SMAC regulate bistable properties of the apoptotic caspase system

S McKenna, L García-Gutiérrez, D Matallanas… - Scientific Reports, 2021 - nature.com
The initiation of apoptosis is a core mechanism in cellular biology by which organisms
control the removal of damaged or unnecessary cells. The irreversible activation of …

[HTML][HTML] MIDAS: mining differentially activated subpaths of KEGG pathways from multi-class RNA-seq data

S Lee, Y Park, S Kim - Methods, 2017 - Elsevier
Pathway based analysis of high throughput transcriptome data is a widely used approach to
investigate biological mechanisms. Since a pathway consists of multiple functions, the …

Non-thermal plasma couples oxidative stress to TRAIL sensitization through DR5 upregulation

SY Hwang, NH Nguyen, TJ Kim, Y Lee… - International Journal of …, 2020 - mdpi.com
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in
various tumor cells without affecting most normal cells. Despite being in clinical testing …

Multilayer network analysis of miRNA and protein expression profiles in breast cancer patients

Y Zhang, J Chen, Y Wang, D Wang, W Cong, BS Lai… - PloS one, 2019 - journals.plos.org
MiRNAs and proteins play important roles in different stages of breast tumor development
and serve as biomarkers for the early diagnosis of breast cancer. A new algorithm that …

[HTML][HTML] Integrated analysis of-omic landscapes in breast cancer subtypes

S Davitavyan, G Martirosyan, G Mkrtchyan… - …, 2024 - f1000research.com
The subtypes of breast cancer exhibit diverse histology, molecular features, therapeutic
response, aggressiveness, and patient outcomes. Multi-omics high-throughput technologies …