In the current vascular interventional environment, high restenosis rates have increased
awareness of the significance of intimal hyperplasia, a chronic structural lesion that …

Antisense oligodeoxynucleotides (ODNs) have great promise as agents for the specific
manipulation of gene expression. Until recently, nonspecific effects of ODNs often …

We studied death of human vascular smooth muscle cells derived from coronary plaques
and normal coronary arteries and aorta. Cells from normal arteries underwent death only …

Nitric oxide is a highly versatile heterodiatomic molecule that effects a variety of actions in
the vasculture. Originally identified as a principal determination of vascular tone, nitric oxide …

Tissue inhibitors of metalloproteinases (TIMPs) are a family of closely related secreted
proteins that limit matrix metalloproteinase (MMP) activity and also have direct effects on cell …

1. Introduction with thiol groups to produce nitrosothiols [9]. Hence, the effects of NO and the
pathophysiological influences on it Vascular smooth muscle cell (VSMC) proliferation is an …

The balance between cell survival and death is under tight genetic control. A multiplicity of
extracellular signals and intracellular mediators is involved in maintaining this balance …

Cardiovascular diseases are a major cause of human death worldwide. Excessive
proliferation of vascular smooth muscle cells contributes to the etiology of such diseases …

Restenosis, an arterial reobstruction occurring in thirty to fifty percent of patients undergoing
coronary angioplasty, because of its localized nature can possibly be best treated by local …

Intimal thickening induced after endothelial denudation of rat aorta is though to be due to
migration and proliferation of smooth muscle cells (SMC). When the reendothelialization is …