Biomarkers can be broadly defined as qualitative or quantitative measurements that convey
information on the physiopathological state of a subject at a certain time point or disease …

Abstract Properties of the local internal environment of the adult brain are tightly controlled
providing a stable milieu essential for its normal function. The mechanisms involved in this …

Serum S100B elevations accurately reflect blood–brain barrier (BBB) damage. Because
S100B is also present in peripheral tissues, release of this protein may not be specific to …

The occludin-like proteins belong to a family of tetraspan transmembrane proteins carrying a
marvel domain. The intrinsic function of the occludin family is not yet clear. Occludin is a …

Chronic liver failure leads to hyperammonemia, a central component in the pathogenesis of
hepatic encephalopathy (HE); however, a correlation between blood ammonia levels and …

The microvasculature plays a central role in the pathophysiology of hemorrhagic shock and
is also involved in arguably all therapeutic attempts to reverse or minimize the adverse …

Therapeutic hypercapnia has the potential for neuroprotection after global cerebral
ischemia. Here we further investigated the effects of different degrees of acute systemic …

Melanocortin peptides induce neuroprotection in acute and chronic experimental
neurodegenerative conditions. Melanocortins likewise counteract systemic responses to …

Abstract Poly (ADP-ribose) polymerase (PARP) is activated by oxidative stress and plays an
important role in traumatic brain injury (TBI). The objective of this study was to investigate …

The nuclear enzyme poly (ADP-ribose) polymerase (PARP) is activated by oxidative stress
and plays a significant role in postischemic brain injury. We assessed the contribution of …