Stroke proteomics: from discovery to diagnostic and therapeutic applications

K Hochrainer, W Yang - Circulation research, 2022 - Am Heart Assoc
Stroke remains a leading cause of death and disability, with limited therapeutic options and
suboptimal tools for diagnosis and prognosis. High throughput technologies such as …

Search for reliable circulating biomarkers to predict carotid plaque vulnerability

N Puig, E Jiménez-Xarrié, P Camps-Renom… - International journal of …, 2020 - mdpi.com
Atherosclerosis is responsible for 20% of ischemic strokes, and the plaques from the internal
carotid artery the most frequently involved. Lipoproteins play a key role in carotid …

HMGB1-triggered inflammation inhibition of notoginseng leaf triterpenes against cerebral ischemia and reperfusion injury via MAPK and NF-κB signaling pathways

W Xie, T Zhu, X Dong, F Nan, X Meng, P Zhou, G Sun… - Biomolecules, 2019 - mdpi.com
Ischemic stroke is a clinically common cerebrovascular disease whose main risks include
necrosis, apoptosis and cerebral infarction, all caused by cerebral ischemia and reperfusion …

RETRACTED ARTICLE: Bone mesenchymal stem cell-derived exosomal microRNA-29b-3p prevents hypoxic-ischemic injury in rat brain by activating the PTEN …

K Hou, G Li, J Zhao, B Xu, Y Zhang, J Yu… - Journal of …, 2020 - Springer
Abstract Background Mesenchymal stem cells (MSCs) are suspected to exert
neuroprotective effects in brain injury, in part through the secretion of extracellular vesicles …

In vitro oxygen glucose deprivation model of ischemic stroke: a proteomics-driven systems biological perspective

M Babu, N Singh, A Datta - Molecular Neurobiology, 2022 - Springer
Oxygen glucose deprivation (OGD) of brain cells is the commonest in vitro model of ischemic
stroke that is used extensively for basic and preclinical stroke research. Protein mass …

Traumatic brain injury recapitulates developmental changes of axons

H Song, C Chen, B Kelley, A Tomasevich, H Lee… - Progress in …, 2022 - Elsevier
During development, half of brain white matter axons are maintained for growth, while the
remainder undergo developmental axon degeneration. After traumatic brain injury (TBI) …

Cucurbitacin B alleviates cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome-mediated inflammation and reducing oxidative stress

X Chu, L Zhang, Y Zhou, Q Fang - Bioscience, Biotechnology …, 2022 - academic.oup.com
Cucurbitacin B (CuB) has been demonstrated to possess anti-inflammatory and
antioxidative properties. However, the effect of CuB on cerebral ischemia/reperfusion (I/R) …

Quantitative proteomic profiling in brain subregions of mice exposed to open-field low-intensity blast reveals position-dependent blast effects

M Jackson, S Chen, P Liu, M Langenderfer, C Li… - Shock Waves, 2024 - Springer
The neurological consequences of combat blast-induced neurotrauma (BINT) pose
important clinical concerns for military service members and veterans. Previous studies have …

Implication of MicroRNA503 in brain endothelial cell function and ischemic stroke

H Zhang, Q Pan, Z Xie, Y Chen, J Wang, J Bihl… - Translational stroke …, 2020 - Springer
The role of miR-503 in brain endothelium and ischemic stroke (IS) remains unclear. We
aimed to study the relationship between plasma miR-503 and the onset time, severity …

Oxidative injury in ischemic stroke: a focus on NADPH oxidase 4

G Li, C Ye, Y Zhu, T Zhang, J Gu, J Pan… - Oxidative Medicine …, 2022 - Wiley Online Library
Ischemic stroke is a leading cause of disability and mortality worldwide. Thus, it is urgent to
explore its pathophysiological mechanisms and find new therapeutic strategies for its …