The parasitic intracellular lifestyle of trypanosomatids: parasitophorous vacuole development and survival

MF Batista, CA Nájera, I Meneghelli… - Frontiers in Cell and …, 2020 - frontiersin.org
The trypanosomatid (protozoan) parasites Trypanosoma cruzi and Leishmania spp. are
causative agents of Chagas disease and Leishmaniasis, respectively. They display high …

From Defense to Dysfunction: Autophagy's Dual Role in Disease Pathophysiology

JA Malik, MA Zafar, S Singh, S Nanda, H Bashir… - European Journal of …, 2024 - Elsevier
Autophagy is a fundamental pillar of cellular resilience, indispensable for maintaining
cellular health and vitality. It coordinates the meticulous breakdown of cytoplasmic …

(‒)-Epicatechin reveals amoebicidal activity against Acanthamoeba castellanii by activating the programmed cell death pathway

HG Lê, JM Kang, TC Võ, WG Yoo, Y Hong, BK Na - Phytomedicine, 2024 - Elsevier
Background Acanthamoeba is an opportunistic pathogen that can cause human infections
such as granulomatous amebic encephalitis and acanthamoeba keratitis. However, no …

Autophagy in the control and pathogenesis of parasitic infections

G Ghartey-Kwansah, F Adu-Nti, B Aboagye, A Ankobil… - Cell & bioscience, 2020 - Springer
Background Autophagy has a crucial role in the defense against parasites. The interplay
existing between host autophagy and parasites has varied outcomes due to the kind of host …

Unique guanidine-conjugated catechins from the leaves of Alchornea rugosa and their autophagy modulating activity

TP Doan, EJ Park, B Ryu, HM Cho, SJ Yoon, GY Jung… - Phytochemistry, 2023 - Elsevier
Natural guanidines, molecules that contain the guanidine moiety, are structurally unique and
often exhibit potent biological activities. A phytochemical investigation of the leaves of …

Autophagy Activated by Peroxiredoxin of Entamoeba histolytica

X Li, Y Zhang, Y Zhao, K Qiao, M Feng, H Zhou… - Cells, 2020 - mdpi.com
Autophagy, an evolutionarily conserved mechanism to remove redundant or dangerous
cellular components, plays an important role in innate immunity and defense against …

A dynamically evolving war between autophagy and pathogenic microorganisms

Q Zheng, L Duan, Y Zhang, J Li, S Zhang… - Journal of Zhejiang …, 2022 - Springer
Autophagy is an intracellular degradation process that maintains cellular homeostasis. It is
essential for protecting organisms from environmental stress. Autophagy can help the host to …

Transcriptome Analysis and Autophagy Investigation of LoVo Cells Stimulated with Exosomes Derived from T. asiatica Adult Worms

P Liang, Y Li, L Mao, T Liu, S Zhang, M Ehsan, L Wang… - Microorganisms, 2021 - mdpi.com
Taenia asiatica is a zoonotic parasite found in the human intestine and pig liver that evolved
various strategies to survive the host's defenses. Exosomes are membranous vesicles …

Discovery of amoebicidal compounds by combining computational and experimental approaches

V Sebastián-Pérez, I Sifaoui… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
Pathogenic and opportunistic free-living amoebae such as Acanthamoeba spp. can cause
keratitis (Acanthamoeba keratitis [AK]), which may ultimately lead to permanent visual …

Host autophagy limits Toxoplasma gondii proliferation in the absence of IFN-γ by affecting the hijack of Rab11A-positive vesicles

L Pan, Y Yang, X Chen, M Zhao, C Yao… - Frontiers in …, 2022 - frontiersin.org
Introduction Autophagy has been recognized as a bona fide immunological process.
Evidence has shown that this process in IFN-γ stimulated cells controls Toxoplasma gondii …