The effective and safe treatment of pain is an unmet health-care need. Current medications
used for pain management are often only partially effective, carry dose-limiting adverse …

There is a pressing need for more effective nonaddictive treatment options for pain. Pain
signals are transmitted from the periphery into the spinal cord via dorsal root ganglion (DRG) …

Abstract Voltage-activated Na+(Na V) channels are crucial contributors to rapid electrical
signaling in the human body. As such, they are among the most targeted membrane proteins …

The sodium channel Nav1. 9 is expressed in the sensory neurons of small diameter dorsal
root ganglia that transmit pain signals, and gain-of-function Nav1. 9 mutations have been …

The axon initial segment (AIS) is a highly specialized neuronal compartment that regulates
the generation of action potentials and maintenance of neuronal polarity. Live imaging of the …

Effective analgesic treatment for neuropathic pain remains an unmet need, so previous
evidence that epidermal growth factor receptor inhibitors (EGFRIs) provide unexpected rapid …

Voltage-gated sodium channel subtypes, Nav1. 7, Nav1. 8, and Nav1. 9 are predominantly
expressed in peripheral sensory neurons. Recent genetic studies have revealed that they …

NaV1. 3 is a subtype of the voltage-gated sodium channel family. It has been implicated in
the pathogenesis of neuropathic pain, although the contribution of this channel to neuronal …

The role of voltage-gated sodium (Na V) channels in pain perception is indisputable. Of
particular interest as targets for the development of pain therapeutics are the tetrodotoxin …

Results We report a 25-year-old consanguineous Turkish woman who presented from
infancy with fluctuating stridor, dysphonia, dyspnoea and limb weakness that persisted for …