[HTML][HTML] Approaches, progress, and challenges to hepatitis C vaccine development

JR Bailey, E Barnes, AL Cox - Gastroenterology, 2019 - Elsevier
Risk factors for hepatitis C virus (HCV) infection vary, and there were an estimated 1.75
million new cases worldwide in 2015. The World Health Organization aims for a 90 …

Understanding the hepatitis C virus life cycle paves the way for highly effective therapies

TKH Scheel, CM Rice - Nature medicine, 2013 - nature.com
More than two decades of intense research has provided a detailed understanding of
hepatitis C virus (HCV), which chronically infects 2% of the world's population. This effort has …

The history of hepatitis C virus (HCV): Basic research reveals unique features in phylogeny, evolution and the viral life cycle with new perspectives for epidemic control

J Bukh - Journal of hepatology, 2016 - Elsevier
The discovery of hepatitis C virus (HCV) in 1989 permitted basic research to unravel critical
components of a complex life cycle for this important human pathogen. HCV is a highly …

[HTML][HTML] Hepatitis C virus RNA functionally sequesters miR-122

JM Luna, TKH Scheel, T Danino, KS Shaw, A Mele… - Cell, 2015 - cell.com
Hepatitis C virus (HCV) uniquely requires the liver-specific microRNA-122 for replication, yet
global effects on endogenous miRNA targets during infection are unexplored. Here, high …

Replication of hepatitis C virus

D Moradpour, F Penin, CM Rice - Nature reviews microbiology, 2007 - nature.com
Exciting progress has recently been made in understanding the replication of hepatitis C
virus, a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma …

Identification of the Niemann-Pick C1–like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor

B Sainz Jr, N Barretto, DN Martin, N Hiraga… - Nature medicine, 2012 - nature.com
Hepatitis C virus (HCV) is a leading cause of liver disease worldwide. With∼ 170 million
individuals infected and current interferon-based treatment having toxic side effects and …

[HTML][HTML] Hepatitis C virus: Morphogenesis, infection and therapy

VA Morozov, S Lagaye - World journal of hepatology, 2018 - ncbi.nlm.nih.gov
Hepatitis C virus (HCV) is a major cause of liver diseases including liver cirrhosis and
hepatocellular carcinoma. Approximately 3% of the world population is infected with HCV …

Hepatitis C virus genotype 7, a new genotype originating from central Africa

DG Murphy, E Sablon, J Chamberland… - Journal of clinical …, 2015 - Am Soc Microbiol
We report a new hepatitis C virus (HCV) genotype identified in patients originating from the
Democratic Republic of Congo. The prototype QC69 virus is shown to be a new lineage …

Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus

E Giang, M Dorner, JC Prentoe… - Proceedings of the …, 2012 - National Acad Sciences
Hepatitis C virus (HCV) infects∼ 2% of the world's population. It is estimated that there are
more than 500,000 new infections annually in Egypt, the country with the highest HCV …

[PDF][PDF] The green tea polyphenol, epigallocatechin‐3‐gallate, inhibits hepatitis C virus entry

S Ciesek, T von Hahn, CC Colpitts, LM Schang… - …, 2011 - Wiley Online Library
Hepatitis C virus (HCV) is a major cause of liver cirrhosis and hepatocellular carcinoma.
Current antiviral therapy fails to clear infection in a substantial proportion of cases. Drug …