Immune cell profiling in atherosclerosis: role in research and precision medicine
DM Fernandez, C Giannarelli - Nature Reviews Cardiology, 2022 - nature.com
Inflammation is intimately involved at all stages of atherosclerosis and remains a substantial
residual cardiovascular risk factor in optimally treated patients. The proof of concept that …
residual cardiovascular risk factor in optimally treated patients. The proof of concept that …
Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis: JACC Macrophage in CVD Series (Part 2)
Atherosclerosis is characterized by the retention of modified lipoproteins in the arterial wall.
These modified lipoproteins activate resident macrophages and the recruitment of monocyte …
These modified lipoproteins activate resident macrophages and the recruitment of monocyte …
Cardiometabolic risk loci share downstream cis-and trans-gene regulation across tissues and diseases
Genome-wide association studies (GWAS) have identified hundreds of cardiometabolic
disease (CMD) risk loci. However, they contribute little to genetic variance, and most …
disease (CMD) risk loci. However, they contribute little to genetic variance, and most …
Relevance of multi-omics studies in cardiovascular diseases
P Leon-Mimila, J Wang… - Frontiers in cardiovascular …, 2019 - frontiersin.org
Cardiovascular diseases are the leading cause of death around the world. Despite the
larger number of genes and loci identified, the precise mechanisms by which these genes …
larger number of genes and loci identified, the precise mechanisms by which these genes …
HDL and atherosclerotic cardiovascular disease: genetic insights into complex biology
RS Rosenson, HB Brewer Jr, PJ Barter… - Nature Reviews …, 2018 - nature.com
Plasma levels of HDL cholesterol (HDL-C) predict the risk of cardiovascular disease at the
epidemiological level, but a direct causal role for HDL in cardiovascular disease remains …
epidemiological level, but a direct causal role for HDL in cardiovascular disease remains …
Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders
Genome-wide association studies (GWAS) have been extensively used to study common
complex diseases such as coronary artery disease (CAD), revealing 153 suggestive CAD …
complex diseases such as coronary artery disease (CAD), revealing 153 suggestive CAD …
[HTML][HTML] Cross-tissue regulatory gene networks in coronary artery disease
Inferring molecular networks can reveal how genetic perturbations interact with
environmental factors to cause common complex diseases. We analyzed genetic and gene …
environmental factors to cause common complex diseases. We analyzed genetic and gene …
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation
Variation in body fat distribution contributes to the metabolic sequelae of obesity. The
genetic determinants of body fat distribution are poorly understood. The goal of this study …
genetic determinants of body fat distribution are poorly understood. The goal of this study …
Risk prediction of cardiovascular events by exploration of molecular data with explainable artificial intelligence
Cardiovascular diseases (CVD) annually take almost 18 million lives worldwide. Most lethal
events occur months or years after the initial presentation. Indeed, many patients experience …
events occur months or years after the initial presentation. Indeed, many patients experience …
Prediction of causal candidate genes in coronary artery disease loci
Objective—Genome-wide association studies have to date identified 159 significant and
suggestive loci for coronary artery disease (CAD). We now report comprehensive …
suggestive loci for coronary artery disease (CAD). We now report comprehensive …