[HTML][HTML] Autoimmune heparin‐induced thrombocytopenia

A Greinacher, K Selleng, TE Warkentin - Journal of Thrombosis and …, 2017 - Elsevier
Autoimmune heparin‐induced thrombocytopenia (aHIT) indicates the presence in patients of
anti‐platelet factor 4 (PF4)–polyanion antibodies that are able to activate platelets strongly …

Pharmacology of heparin and related drugs: An update

J Hogwood, B Mulloy, R Lever, E Gray, CP Page - Pharmacological reviews, 2023 - ASPET
Heparin has been used extensively as an antithrombotic and anticoagulant for close to 100
years. This anticoagulant activity is attributed mainly to the pentasaccharide sequence …

Antibody epitopes in vaccine-induced immune thrombotic thrombocytopaenia

A Huynh, JG Kelton, DM Arnold, M Daka, I Nazy - Nature, 2021 - nature.com
Vaccine-induced immune thrombotic thrombocytopaenia (VITT) is a rare adverse effect of
COVID-19 adenoviral vector vaccines,–. VITT resembles heparin-induced …

Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination

A Greinacher, T Thiele, TE Warkentin… - … England Journal of …, 2021 - Mass Medical Soc
Background Several cases of unusual thrombotic events and thrombocytopenia have
developed after vaccination with the recombinant adenoviral vector encoding the spike …

Recommendations for the clinical and laboratory diagnosis of VITT against COVID‐19: communication from the ISTH SSC Subcommittee on Platelet Immunology

I Nazy, UJ Sachs, DM Arnold… - … of Thrombosis and …, 2021 - Wiley Online Library
Vaccine administration is under way worldwide to combat the current COVID‐19 pandemic.
The newly developed vaccines are highly effective with minimal adverse effects. Recently …

Adjunct immune globulin for vaccine-induced immune thrombotic thrombocytopenia

A Bourguignon, DM Arnold, TE Warkentin… - … England Journal of …, 2021 - Mass Medical Soc
The use of high-dose intravenous immune globulin (IVIG) plus anticoagulation is
recommended for the treatment of vaccine-induced immune thrombotic thrombocytopenia …

Anti-PF4 immunothrombosis without proximate heparin or adenovirus vector vaccine exposure

L Schönborn, O Esteban, J Wesche, P Dobosz, M Broto… - Blood, 2023 - ashpublications.org
Platelet-activating anti-platelet factor 4 (PF4)/heparin antibodies and anti-PF4 antibodies
cause heparin-induced thrombocytopenia (HIT) and vaccine-induced immune …

Laboratory diagnosis of heparin‐induced thrombocytopenia

TE Warkentin - International journal of laboratory hematology, 2019 - Wiley Online Library
Heparin‐induced thrombocytopenia (HIT) is a clinical‐pathological disorder; thus, laboratory
testing for the pathogenic platelet‐activating antiplatelet factor 4 (PF 4)/heparin antibodies is …

Reverse engineering of a pathogenic antibody reveals the molecular mechanism of vaccine-induced immune thrombotic thrombocytopenia

DG Ivanov, N Ivetic, Y Du, SN Nguyen… - Journal of the …, 2023 - ACS Publications
The massive COVID-19 vaccine roll-out campaign illuminated a range of rare side effects,
the most dangerous of which─ vaccine-induced immune thrombotic thrombocytopenia …

[HTML][HTML] Investigation of anti-PF4 versus anti-PF4/heparin reactivity using fluid-phase enzyme immunoassay for 4 anti-PF4 disorders: classic heparin-induced …

TE Warkentin, DM Arnold, JAI Sheppard… - Journal of Thrombosis …, 2023 - Elsevier
Background Four platelet-activating anti-platelet factor 4 (PF4) disorders have been
recognized: classic heparin-induced thrombocytopenia (cHIT), autoimmune heparin …