Molecular and pathogenic effects of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in MHC-I-associated inflammatory disorders: towards a unifying view
JAL de Castro, C Alvarez-Navarro, A Brito, P Guasp… - Molecular …, 2016 - Elsevier
The inflammatory diseases that are most strongly associated with major histocompatibility
Complex class I (MHC-I) alleles are also influenced by endoplasmic reticulum …
Complex class I (MHC-I) alleles are also influenced by endoplasmic reticulum …
ERAP Inhibitors in Autoimmunity and Immuno-Oncology: Medicinal Chemistry Insights
V Fougiaxis, B He, T Khan, R Vatinel… - Journal of Medicinal …, 2024 - ACS Publications
Endoplasmic reticulum aminopeptidases ERAP1 and 2 are intracellular aminopeptidases
that trim antigenic precursors and generate antigens presented by major histocompatibility …
that trim antigenic precursors and generate antigens presented by major histocompatibility …
Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling
P Kasperkiewicz, M Poreba… - Proceedings of the …, 2014 - National Acad Sciences
The exploration of protease substrate specificity is generally restricted to naturally occurring
amino acids, limiting the degree of conformational space that can be surveyed. We …
amino acids, limiting the degree of conformational space that can be surveyed. We …
Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses
E Zervoudi, E Saridakis, JR Birtley… - Proceedings of the …, 2013 - National Acad Sciences
Intracellular aminopeptidases endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and
ERAP2), and as well as insulin-regulated aminopeptidase (IRAP) process antigenic epitope …
ERAP2), and as well as insulin-regulated aminopeptidase (IRAP) process antigenic epitope …
Structural basis for antigenic peptide recognition and processing by endoplasmic reticulum (ER) aminopeptidase 2
Endoplasmic reticulum (ER) aminopeptidases process antigenic peptide precursors to
generate epitopes for presentation by MHC class I molecules and help shape the antigenic …
generate epitopes for presentation by MHC class I molecules and help shape the antigenic …
The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing
Endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 cooperate to trim a vast variety
of antigenic peptide precursors to generate mature epitopes for binding to major …
of antigenic peptide precursors to generate mature epitopes for binding to major …
The roles of ERAP1 and ERAP2 in autoimmunity and cancer immunity: New insights and perspective
F Babaie, R Hosseinzadeh, M Ebrazeh… - Molecular …, 2020 - Elsevier
Autoimmunity and cancer affect millions worldwide and both, in principal, result from
dysregulated immune responses. There are many well-known molecules involved in …
dysregulated immune responses. There are many well-known molecules involved in …
ERAP1–ERAP2 dimerization increases peptide-trimming efficiency
I Evnouchidou, M Weimershaus, L Saveanu… - The Journal of …, 2014 - journals.aai.org
The endoplasmic reticulum aminopeptidases (ERAP) 1 and ERAP2 play a critical role in the
production of final epitopes presented by MHC class I molecules. Formation of heterodimers …
production of final epitopes presented by MHC class I molecules. Formation of heterodimers …
A role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition
E Stratikos, A Stamogiannos, E Zervoudi… - Frontiers in oncology, 2014 - frontiersin.org
Endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1 and ERAP2) are key components
on the pathway that generates antigenic epitopes for presentation to cytotoxic T-lymphocytes …
on the pathway that generates antigenic epitopes for presentation to cytotoxic T-lymphocytes …
Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase
A Mpakali, I Barla, L Lu, KM Ramesh… - Journal of Molecular …, 2024 - Elsevier
Abstract Inhibition of Insulin-Regulated Aminopeptidase is being actively explored for the
treatment of several human diseases and several classes of inhibitors have been developed …
treatment of several human diseases and several classes of inhibitors have been developed …