Tissues have a natural capacity to replace dying cells and to heal wounds. This ability
resides in resident stem cells, which self-renew, preserve, and repair their tissue during …

The WNT signal transduction cascade controls myriad biological phenomena throughout
development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a …

The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

There were multiple prerequisites to the evolution of multicellular animal life, including the
generation of multiple cell fates (" cellular diversity") and their patterned spatial arrangement …

Wnt genes and components of Wnt signalling pathways have been implicated in a wide
spectrum of important biological phenomena, ranging from early organismal development to …

Wnt/β-Catenin signaling plays key roles in tissue homeostasis and cell fate decisions in
embryonic and post-embryonic development across the animal kingdom. As a result …

Developmental signals such as Wnts are often presented to cells in an oriented manner. To
examine the consequences of local Wnt signaling, we immobilized Wnt proteins on beads …

Stem cells (SCs) govern tissue homeostasis and wound repair. They reside within niches,
the special microenvironments within tissues that control SC lineage outputs. Upon injury or …

Polarity establishment, asymmetric division, and acquisition of cell fates are critical steps
during earlydevelopment. In this review, we discuss processes that set up the embryonic …

If Narcissus could have self‐renewed even once on seeing his own reflection, he would
have died a happy man. Stem cells, on the other hand, have an enormous capacity for self …