SIRT1: a potential therapeutic target in autoimmune diseases

P Shen, X Deng, Z Chen, X Ba, K Qin, Y Huang… - Frontiers in …, 2021 - frontiersin.org
The morbidity and mortality of autoimmune diseases (Ads) have been increasing worldwide,
and the identification of novel therapeutic strategies for prevention and treatment is urgently …

The role of reactive oxygen species in the rheumatoid arthritis-associated synovial microenvironment

X Wang, D Fan, X Cao, Q Ye, Q Wang, M Zhang… - Antioxidants, 2022 - mdpi.com
Rheumatoid arthritis (RA) is an inflammatory disease that begins with a loss of tolerance to
modified self-antigens and immune system abnormalities, eventually leading to synovitis …

FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis

D Guo, C Lin, Y Lu, H Guan, W Qi, H Zhang, Y Shao… - Bone Research, 2022 - nature.com
Increasing evidence shows that adipokines play a vital role in the development of
rheumatoid arthritis (RA). Fatty acid-binding protein 4 (FABP4), a novel adipokine that …

β-Sitosterol inhibits rheumatoid synovial angiogenesis through suppressing VEGF signaling pathway

K Qian, XX Zheng, C Wang, WG Huang… - Frontiers in …, 2022 - frontiersin.org
Background: Rheumatoid arthritis (RA) is a chronic disabling inflammatory disease that
causes synovial angiogenesis in an invasive manner and leads to joint destruction …

[HTML][HTML] The enhanced mitochondrial dysfunction by cantleyoside confines inflammatory response and promotes apoptosis of human HFLS-RA cell line via AMPK/Sirt …

J Bai, N Xie, Y Hou, X Chen, Y Hu, Y Zhang… - Biomedicine & …, 2022 - Elsevier
Objective Cantleyoside (CA) is a kind of iridoid glycosides in Pterocephalus hookeri (CB
Clarke) Höeck. The purpose of this study was to investigate the effects of CA on human …

Semaphorins: From angiogenesis to inflammation in rheumatoid arthritis

J Avouac, S Pezet, E Vandebeuque… - Arthritis & …, 2021 - Wiley Online Library
Objective To study the potential role of semaphorins in the pathogenesis of rheumatoid
arthritis (RA). Methods Microarray experiments were performed on Affymetrix GeneChip …

The interplay between fibroblast‐like synovial and vascular endothelial cells leads to angiogenesis via the sphingosine‐1‐phosphate‐induced RhoA‐F‐Actin and Ras …

R Deng, Y Bu, F Li, H Wu, Y Wang… - Phytotherapy …, 2021 - Wiley Online Library
The changes of fibroblast‐like synoviocytes (FLSs) and vascular endothelial cells (VECs)
biological functions are closely related to angiogenesis in rheumatoid arthritis (RA) …

Gene polymorphisms of SIRT1 in patients with rheumatoid arthritis

J Zhou, YW He, L Fu, YY Lan, XY Liu… - International Journal …, 2022 - Wiley Online Library
Aim Previous studies have shown that silent information regulator 1 (SIRT1) expression is
elevated in rheumatoid arthritis (RA) patients. However, whether gene polymorphisms in …

A detective story of intermittent fasting effect on immunity

R Ma - Immunology, 2024 - Wiley Online Library
Intermittent fasting (IF) refers to periodic fasting routines, that caloric intake is minimized not
by meal portion size reduction but by intermittently eliminating ingestion of one or several …

[PDF][PDF] SIRT1/FOXO1 axis-mediated hippocampal angiogenesis is involved in the antidepressant effect of Chaihu Shugan San

S Zhang, Y Lu, W Shi, Y Ren, K Xiao… - Drug Design …, 2022 - Taylor & Francis
Objective Chaihu Shugan San (CSS) has a long history for treating major depressive
disorder (MDD), which has been verified effectively and safely in clinical studies. Deficient …