Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance

W Wu, JL Klockow, M Zhang, F Lafortune… - Pharmacological …, 2021 - Elsevier
Glioblastoma multiforme (GBM) is a WHO grade IV glioma and the most common malignant,
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …

Emerging ultrasonic bioelectronics for personalized healthcare

L Jiang, J Wu - Progress in Materials Science, 2023 - Elsevier
Emerging ultrasonic bioelectronics (UBEs) with wearable, implantable or highly integrated
forms enable continuous health monitoring and on-demand medical therapy at the point of …

SEC61G assists EGFR-amplified glioblastoma to evade immune elimination

K Zeng, Y Zeng, H Zhan, Z Zhan… - Proceedings of the …, 2023 - National Acad Sciences
Amplification of chromosome 7p11 (7p11) is the most common alteration in primary
glioblastoma (GBM), resulting in gains of epidermal growth factor receptor (EGFR) copy …

Research progress in inducing immunogenic cell death of tumor cells

D Xie, Q Wang, G Wu - Frontiers in immunology, 2022 - frontiersin.org
Immunogenic cell death (ICD) is a regulated cell death (RCD) pathway. In response to
physical and chemical signals, tumor cells activate specific signaling pathways that stimulate …

DNA damage response inhibitors enhance tumour treating fields (TTFields) potency in glioma stem-like cells

A Vanderlinden, CG Jones, KN Myers… - British Journal of …, 2023 - nature.com
Background High-grade gliomas are primary brain cancers with unacceptably low and
persistent survival rates of 10–16 months for WHO grade 4 gliomas over the last 40 years …

Tyrosine kinase inhibitors for glioblastoma multiforme: challenges and opportunities for drug delivery

HK Brar, J Jose, Z Wu, M Sharma - Pharmaceutics, 2022 - mdpi.com
Glioblastoma multiforme (GBM) is an aggressive brain tumor with high mortality rates. Due to
its invasiveness, heterogeneity, and incomplete resection, the treatment is very challenging …

Glioblastoma therapy: past, present and future

E Obrador, P Moreno-Murciano… - International journal of …, 2024 - mdpi.com
Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer.
Although great efforts have been made by clinicians and researchers, no significant …

How Can Static and Oscillating Electric Fields Serve in Decomposing Alzheimer's and Other Senile Plaques?

S Kalita, H Bergman, KD Dubey… - Journal of the American …, 2023 - ACS Publications
Alzheimer's disease is one of the most common neurodegenerative conditions, which are
ascribed to extracellular accumulation of β-amyloid peptides into plaques. This …

[HTML][HTML] Engineered smart materials for RNA based molecular therapy to treat Glioblastoma

RR Singh, I Mondal, T Janjua, A Popat… - Bioactive Materials, 2024 - Elsevier
Glioblastoma (GBM) is an aggressive malignancy of the central nervous system (CNS) that
remains incurable despite the multitude of improvements in cancer therapeutics. The …

PARP inhibitors in glioma: a review of therapeutic opportunities

HW Sim, E Galanis, M Khasraw - Cancers, 2022 - mdpi.com
Simple Summary There is a pressing need for new effective treatments against glioma. A
promising option is a class of drugs called poly (ADP-Ribose) polymerase (PARP) inhibitors …