Point-of-care diagnosis based on nucleic acid testing aims to incorporate all the analytical
steps, from sample preparation to nucleic acid amplification and detection, in a single …

The capacity to diversify genetic codes advances our ability to understand and engineer
biological systems,. A method for continuously diversifying user-defined regions of a …

DNA origami nano-objects are usually designed around generic single-stranded “scaffolds”.
Many properties of the target object are determined by details of those generic scaffold …

Scaffolded DNA origami enables the fabrication of a variety of complex nanostructures that
promise utility in diverse fields of application, ranging from biosensing over advanced …

Bacillus subtilis phage Φ29 has a linear, double-stranded DNA 19 kb long with an inverted
terminal repeat of 6 nucleotides and a protein covalently linked to the 5′ ends of the DNA …

Chromosome-derived extrachromosomal circular DNA elements (eccDNAs) are detected in
all eukaryotes examined so far. Here I describe the Circle-Seq protocol, applicable for …

Nanopore sequencing offers a portable and affordable alternative to sequencing-by-
synthesis methods but suffers from lower accuracy and cannot sequence ultrashort DNA …

Cell-SELEX is a powerful tool to screen aptamers binding to living cellular organisms such
as bacteria, fungi and even oncocytes. Here, we developed an advanced cell-SELEX …

The ability of begomoviruses to evolve rapidly threatens many crops and underscores the
importance of detecting these viruses quickly and to understand their genome diversity. This …

Single-stranded (ss) DNA nanostructures (DNs), created by unimolecular folding of kilo-
based ssDNA, represent a new class of DNA constructs suitable for biomaterial and …