Dynamics and function of the tear film in relation to the blink cycle
Great strides have recently been made in quantitative measurements of tear film thickness
and thinning, mathematical modeling thereof and linking these to sensory perception. This …
and thinning, mathematical modeling thereof and linking these to sensory perception. This …
Evaporation-driven instability of the precorneal tear film
Tear-film instability is widely believed to be a signature of eye health. When an interblink is
prolonged, randomly distributed ruptures occur in the tear film.“Black spots” and/or “black …
prolonged, randomly distributed ruptures occur in the tear film.“Black spots” and/or “black …
[HTML][HTML] Mechanobiology of the corneal epithelium
S Masterton, M Ahearne - Experimental eye research, 2018 - Elsevier
There has been a drive to develop new cell based therapies to treat corneal blindness, one
of the most common causes of blindness worldwide. Mechanical and physical cues are …
of the most common causes of blindness worldwide. Mechanical and physical cues are …
[HTML][HTML] An integrated microfluidic concentration gradient generator for mechanical stimulation and drug delivery
Mechanical stimuli, including fluid shear stress, osmotic pressure gradient, and extracellular
matrix stiffness, significantly affect cellular interactions with drugs in biological structures …
matrix stiffness, significantly affect cellular interactions with drugs in biological structures …
Mechanistic modeling of ophthalmic drug delivery to the anterior chamber by eye drops and contact lenses
S Gause, KH Hsu, C Shafor, P Dixon, KC Powell… - Advances in colloid and …, 2016 - Elsevier
Ophthalmic drug for the anterior chamber diseases are delivered into tears by either eye
drops or by extended release devices placed in the eyes. The instilled drug exits the eye …
drops or by extended release devices placed in the eyes. The instilled drug exits the eye …
Development and characterization of nanoemulsions for ophthalmic applications: Role of cationic surfactants
AR Fernandes, E Sanchez-Lopez, T Santos, ML Garcia… - Materials, 2021 - mdpi.com
The eye is a very complex organ comprising several physiological and physical barriers that
compromise drug absorption into deeper layers. Nanoemulsions are promising delivery …
compromise drug absorption into deeper layers. Nanoemulsions are promising delivery …
[HTML][HTML] Antimicrobial peptides loaded collagen nanosheets with enhanced antibacterial activity, corneal wound healing and M1 macrophage polarization in bacterial …
H Huang, Y Xie, J Zhong, Z Fu, P Wu, X Chen… - Composites Part B …, 2024 - Elsevier
Bacterial keratitis is one of the leading causes of blindness in the world. Frequent
administration of antibiotic eye drops is the first-line treatment, which has difficulties in …
administration of antibiotic eye drops is the first-line treatment, which has difficulties in …
Fluid reservoir thickness and corneal edema during open-eye scleral lens wear
PURPOSE The purpose of this study was to examine the effect of altering the fluid reservoir
thickness on central corneal edema during short-term open-eye scleral lens wear and to …
thickness on central corneal edema during short-term open-eye scleral lens wear and to …
Hypoxia adaptation in the cornea: Current animal models and underlying mechanisms
The cornea is an avascular, transparent tissue that is essential for visual function. Any
disturbance to the corneal transparency will result in a severe vision loss. Due to the …
disturbance to the corneal transparency will result in a severe vision loss. Due to the …
Corneal endothelial cells over the past decade: are we missing the mark (er)?
B Van den Bogerd, N Zakaria, B Adam… - … vision science & …, 2019 - tvst.arvojournals.org
Corneal endothelial dysfunction is one of the leading causes of corneal edema and visual
impairment, requiring corneal endothelial transplantation. The treatments are limited …
impairment, requiring corneal endothelial transplantation. The treatments are limited …