Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …

Members of the Flaviviridae virus family comprise a large group of enveloped viruses with a
single-strand RNA genome of positive polarity. Several genera belong to this family …

Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging
Zika virus, are an increasing and probably lasting global risk. This Review summarizes and …

Antiviral drugs have traditionally been developed by directly targeting essential viral
components. However, this strategy often fails due to the rapid generation of drug-resistant …

When viruses infect cells, they almost invariably cause metabolic changes in the infected
cell as well as in several host cell types that react to the infection. Such metabolic changes …

Viral replication is a process that involves an extremely high turnover of cellular molecules.
Since viruses depend on the host cell to obtain the macromolecules needed for their proper …

The ongoing COVID-19 pandemic, periodic recurrence of viral infections, and the
emergence of challenging variants has created an urgent need of alternative therapeutic …

Coronaviruses rely on host membranes for entry, establishment of replication centers, and
egress. Compounds targeting cellular membrane biology and lipid biosynthetic pathways …

Mosquito-borne diseases are associated with major global health burdens. Aedes spp. and
Culex spp. are primarily responsible for the transmission of the most medically important …

The Usutu virus (USUV) is a flavivirus that is drawing increasing attention because of its
potential for emergence. First isolated in Africa, it was introduced into Europe where it …