Artemisia annua L. is used throughout Asia and Africa as tea and press juice to treat malaria
and related symptomes (fever, chills). Its active ingredient, artemisinin (ARS), has been …

Abstract Each year, about 5–6 cases out of 100,000 people are diagnosed with primary
malignant brain tumors, of which about 80% are malignant gliomas (MGs). Glioblastoma …

The antimalarial drug artemisinin and its derivatives have been explored as potential
anticancer agents, but their underlying mechanisms are controversial. In this study, we found …

Artesunate, an anti-malarial drug, has been repurposed as an anticancer drug due to its
induction of cell death via reactive oxygen species (ROS) production. However, the …

Oncogenic KRas reprograms pancreatic ductal adenocarcinoma (PDAC) cells to states
which are highly resistant to apoptosis. Thus, a major preclinical goal is to identify effective …

Malaria is a highly inflammatory and oxidative disease. The production of reactive oxygen
species by host phagocytes is an essential component of the host response to Plasmodium …

The effective treatment of glioblastoma (GBM) is a great challenge because of the blood-
brain barrier (BBB) and the growing resistance to single-agent therapeutics. Targeted …

Artemisinin and its derivatives (collectively termed as artemisinins) are among the most
important and effective antimalarial drugs, with proven safety and efficacy in clinical use …

Cisplatin, which induces DNA damage, is standard chemotherapy for advanced bladder
cancer (BCa). However, efficacy is limited due to resistance development. Since artesunate …

Artemisinin and its derivatives represent the most important and influential class of drugs in
the fight against malaria. Since the discovery of artemisinin in the early 1970s, the global …