Fibrinogen is a large, complex, fibrous glycoprotein with three pairs of polypeptide chains
linked together by 29 disulfide bonds. It is 45 nm in length, with globular domains at each …

New biological materials for tissue engineering are now being developed using common
genetic engineering capabilities to clone and express a variety of genetic elements that …

Ten specially synthesized polyurethanes (PUs) were used to investigate the effects of
surface properties on platelet adhesion. Surface composition and hydrophilicity, fibrinogen …

Fibrinogen binding to the integrin αIIbβ3 mediates platelet aggregation and spreading on
fibrinogen-coated surfaces. However, in vivo αIIbβ3 activation and fibrinogen conversion to …

ADP plays a central role in regulating platelet function. It induces platelet aggregation via the
activation of 2 major ADP receptors, P2Y1 and P2Y12. We have investigated the role of …

The currently available antithrombotic agents target the interaction of platelet integrin α IIb β
3 (GPIIb-IIIa) with fibrinogen during platelet aggregation. Platelets also bind fibrin formed …

Introduction 3. Thrombin-mediated platelet activation 3.1. Platelet activation via protease
activated receptors 3.1. 1. Activation of human platelets 3.1. 2. Activation of murine platelets …

The impact of ligand density on integrin-mediated cell adhesion and outside-in signaling is
not well understood. Using total internal reflection fluorescent microscopy, conformation …

This study demonstrates that two orthogonal events regulate integrin αIIbβ3's interactions
with fibrinogen, its primary physiological ligand:(1) conformational changes at the αIIb− β3 …

Platelet integrin receptor αIIbβ3 supports platelet aggregation by binding fibrinogen. The
interaction between the fibrinogen C-terminal γ-chain peptide composed of residues γ-404 …