Genotype× environment interactions (GxE) have long been recognized as a key mechanism
underlying human phenotypic variation. Technological developments over the past 15 years …

Background Several risk factors for asthma have been proposed; however, the causality of
these associations is sometimes unclear. Mendelian randomization is a powerful …

The impact of genetic variants on cells challenged in biologically relevant contexts has not
been fully explored. Here, we activated CD4+ T cells from 89 healthy donors and performed …

Abstract Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of
insulin-producing pancreatic islet beta cells. Despite significant advancements, the precise …

Common genetic polymorphisms associated with COVID-19 illness can be utilized for
discovering molecular pathways and cell types driving disease pathogenesis. Given the …

Expression quantitative trait loci (eQTL) studies are used to understand the regulatory
function of non-coding genome-wide association study (GWAS) risk loci, but colocalization …

Synthetic glucocorticoids, such as dexamethasone, have been used as a treatment for many
immune conditions, such as asthma and, more recently, severe COVID-19. Single-cell data …

Background Many plant species exhibit genetic variation for coping with environmental
stress. However, there are still limited approaches to effectively uncover the genomic region …

Vascular smooth muscle cell (VSMC) proliferation, migration, and apoptosis play important
roles in many physiological processes and pathological conditions. To identify genetic …

Environmental triggers have important functions in multiple sclerosis (MS) susceptibility,
phenotype, and trajectory. Exposure to early life trauma (ELT) has been associated with …