New insights into acute pancreatitis

PJ Lee, GI Papachristou - Nature reviews Gastroenterology & …, 2019 - nature.com
The incidence of acute pancreatitis continues to increase worldwide, and it is one of the
most common gastrointestinal causes for hospital admission in the USA. In the past decade …

[HTML][HTML] Intestinal barrier damage, systemic inflammatory response syndrome, and acute lung injury: A troublesome trio for acute pancreatitis

P Ge, Y Luo, CS Okoye, H Chen, J Liu, G Zhang… - Biomedicine & …, 2020 - Elsevier
Severe acute pancreatitis (SAP), a serious inflammatory disease of the pancreas, can easily
lead to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction …

Bifidobacterium spp. and their metabolite lactate protect against acute pancreatitis via inhibition of pancreatic and systemic inflammatory responses

H Li, J Xie, X Guo, G Yang, B Cai, J Liu, M Yue… - Gut …, 2022 - Taylor & Francis
Severe acute pancreatitis (SAP) is a critical illness characterized by a severe systemic
inflammatory response resulting in persistent multiple organ failure and sepsis. The …

[HTML][HTML] A narrative review of acute pancreatitis and its diagnosis, pathogenetic mechanism, and management

Z Zheng, YX Ding, YX Qu, F Cao, F Li - Annals of translational …, 2021 - ncbi.nlm.nih.gov
Acute pancreatitis (AP) is an inflammatory disease that can progress to severe acute
pancreatitis (SAP), which increases the risk of death. AP is characterized by inappropriate …

[HTML][HTML] Prussian blue nanozyme-mediated nanoscavenger ameliorates acute pancreatitis via inhibiting TLRs/NF-κB signaling pathway

X Xie, J Zhao, W Gao, J Chen, B Hu, X Cai, Y Zheng - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Acute pancreatitis (AP) is a serious acute condition affecting the abdomen and
shows high morbidity and mortality rates. Its global incidence has increased in recent years …

The Orai Ca2+ channel inhibitor CM4620 targets both parenchymal and immune cells to reduce inflammation in experimental acute pancreatitis

RT Waldron, Y Chen, H Pham, A Go… - The Journal of …, 2019 - Wiley Online Library
Key points This work confirms previous reports that CM4620, a small molecule inhibitor of
Ca2+ entry via store operated Ca2+ entry (SOCE) channels formed by stromal interaction …

Lure-and-kill macrophage nanoparticles alleviate the severity of experimental acute pancreatitis

Q Zhang, J Zhou, J Zhou, RH Fang, W Gao… - Nature …, 2021 - nature.com
Acute pancreatitis is a disease associated with suffering and high lethality. Although the
disease mechanism is unclear, phospholipase A2 (PLA2) produced by pancreatic acinar …

The melatonin receptor agonist agomelatine protects against acute pancreatitis induced by cadmium by attenuating inflammation and oxidative stress and modulating …

RS Alruhaimi, EHM Hassanein, MK Abd El-Aziz… - International …, 2023 - Elsevier
Pancreatitis is a serious effect of the heavy metal cadmium (Cd) and inflammation and
oxidative stress (OS) are implicated in Cd-induced pancreatic injury. This study evaluated …

Synthesis of Prussian blue nanoparticles and their antibacterial, antiinflammation and antitumor applications

D Li, M Liu, W Li, Q Fu, L Wang, E Lai, W Zhao… - Pharmaceuticals, 2022 - mdpi.com
In recent years, Prussian blue nanoparticles (PBNPs), also named Prussian blue nano-
enzymes, have been shown to demonstrate excellent multi-enzyme simulation activity and …

[HTML][HTML] TMEM16A Ca2+-activated Cl− channel inhibition ameliorates acute pancreatitis via the IP3R/Ca2+/NFκB/IL-6 signaling pathway

Q Wang, L Bai, S Luo, T Wang, F Yang, J Xia… - Journal of advanced …, 2020 - Elsevier
Abstract TMEM16A Ca 2+-activated Cl− channels are expressed in pancreatic acinar cells
and participate in inflammation-associated diseases. Whether TMEM16A contributes to the …