The nucleolus is a membrane-less organelle formed through liquid-liquid phase separation
of its components from the surrounding nucleoplasm. Here, we show that nucleophosmin …

High-density lipoprotein (HDL) particles are cholesterol and lipid transport containers.
Mature HDL particles destined for the liver develop through the formation of intermediate …

Background To understand the mechanisms related to the 'dynamical ordering'of
macromolecules and biological systems, it is crucial to monitor, in detail, molecular …

Highlights•Modern NMR methods have enabled detailed characterization of large protein
complexes.•NMR-active isotopes are incorporated uniformly or in defined parts of a …

Detergents are often used to investigate the structure and dynamics of membrane proteins.
Whereas the structural integrity seems to be preserved in detergents for many membrane …

A trimer-of-hairpins motif has been identified in triggering virus-cell fusion within a variety of
viral envelopes. Chemically manipulating such a motif represents current repertoire of viral …

Papain-like protease (PLpro) from severe acute respiratory syndrome Coronavirus 2 (SARS-
CoV-2) is a prime target for the development of antivirals for Coronavirus disease 2019 …

The C-terminal transmembrane domain (TMD) of viral fusion proteins such as HIV gp41 and
influenza hemagglutinin (HA) is traditionally viewed as a passive α-helical anchor of the …

The HIV-1 glycoprotein, gp41, mediates fusion of the virus lipid envelope with the target cell
membrane during virus entry into cells. Despite extensive studies of this protein, inconsistent …

Protein tyrosine kinases differ widely in their propensity to undergo rearrangements of the N-
terminal Asp–Phe–Gly (DFG) motif of the activation loop, with some, including FGFR1 …