Mood disorders are common and debilitating conditions characterized in part by profound
deficits in reward-related behavioural domains. A recent literature has identified important …

Major depressive disorder (MDD) will affect one out of every five people in their lifetime and
is the leading cause of disability worldwide. Nevertheless, mechanisms associated with the …

The variety of physiological functions controlled by dopamine in the brain and periphery is
mediated by the D 1, D 2, D 3, D 4 and D 5 dopamine GPCRs. Drugs acting on dopamine …

Clinically significant depression is present in one of every four people with type 2 diabetes
mellitus (T2DM). Depression increases the risk of the development of T2DM and the …

Stress-related neuropsychiatric disorders, such as major depressive disorder and
posttraumatic stress disorder, exact enormous socioeconomic and individual consequences …

Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have
met with limited success. We sought to increase statistical power to detect disease loci by …

The neurobiology of stress and the neurobiology of social behavior are deeply intertwined.
The social environment interacts with stress on almost every front: social interactions can be …

Basic and clinical studies demonstrate that depression is associated with reduced size of
brain regions that regulate mood and cognition, including the prefrontal cortex and the …

Background The nucleus accumbens is a critical mediator of depression-related outcomes
to social defeat stress. Previous studies demonstrate distinct neuroplasticity adaptations in …

Basic and clinical studies demonstrate that stress and depression are associated with
atrophy and loss of neurons and glia, which contribute to the decreased size and function of …