We review here the advances in the understanding of the immunopathology of human
paracoccidioidomycosis (PCM). Its investigation must take in account the intriguing natural …

Paracoccidioidomycosis is the most prevalent systemic endemic mycosis in South America
with most reported cases in Brazil. It is a major cause of disability and death among young …

Fungal infections represent a serious global health problem, causing damage to health and
the economy on the scale of millions. Although vaccines are the most effective therapeutic …

T cell epitope-driven vaccine design employs bioinformatic algorithms to identify potential
targets of vaccines against infectious diseases or cancer. Potential epitopes can be …

Peptides are remarkably reactive molecules produced by a great variety of species and able
to display a number of functions in uni-and multicellular organisms as mediators, agonists …

Paracoccidioidomycosis (PCM) is a systemic granulomatous disease caused by the
dimorphic fungus Paracoccidioides brasiliensis. Anti-PCM vaccine formulations based on …

The etiology of rheumatic fever and rheumatic heart disease (RF/RHD) is believed to be
autoimmune, involving immune responses initiated between streptococcal and host tissue …

Current therapies against malignant melanoma generally fail to increase survival in most
patients, and immunotherapy is a promising approach as it could reduce the dosage of toxic …

Paracoccidioidomycosis is a systemic granulomatous disease caused by Paracoccidioides
spp. A peptide from the major diagnostic antigen gp43, named P10, induces a T-CD4+ …

Paracoccidioidomycosis is a systemic granulomatous disease manifested in the
acute/subacute or chronic forms. The anergic cases of the acute/subacute form are most …