Class II PI3K functions in cell biology and disease
The phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that phosphorylate
inositol phospholipids, thereby controlling membrane lipid composition and regulating a …
inositol phospholipids, thereby controlling membrane lipid composition and regulating a …
Regulation of autophagy by kinases
S Sridharan, K Jain, A Basu - Cancers, 2011 - mdpi.com
Autophagy is a process of self-degradation that maintains cellular viability during periods of
metabolic stress. Although autophagy is considered a survival mechanism when faced with …
metabolic stress. Although autophagy is considered a survival mechanism when faced with …
Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function
K Yoshioka, K Yoshida, H Cui, T Wakayama… - Nature medicine, 2012 - nature.com
The class II α-isoform of phosphatidylinositol 3-kinase (PI3K-C2α) is localized in
endosomes, the trans-Golgi network and clathrin-coated vesicles; however, its functional …
endosomes, the trans-Golgi network and clathrin-coated vesicles; however, its functional …
Regulation and cellular functions of class II phosphoinositide 3-kinases
M Falasca, T Maffucci - Biochemical Journal, 2012 - portlandpress.com
Class II isoforms of PI3K (phosphoinositide 3-kinase) are still the least investigated and
characterized of all PI3Ks. In the last few years, an increased interest in these enzymes has …
characterized of all PI3Ks. In the last few years, an increased interest in these enzymes has …
Cholinergic receptor pathways involved in apoptosis, cell proliferation and neuronal differentiation
RR Resende, A Adhikari - Cell Communication and Signaling, 2009 - Springer
Acetylcholine (ACh) has been shown to modulate neuronal differentiation during early
development. Both muscarinic and nicotinic acetylcholine receptors (AChRs) regulate a …
development. Both muscarinic and nicotinic acetylcholine receptors (AChRs) regulate a …
Regulation of smooth muscle contraction by small GTPases
S Puetz, LT Lubomirov, G Pfitzer - Physiology, 2009 - journals.physiology.org
Next to changes in cytosolic [Ca2+], members of the Rho subfamily of small GTPases, in
particular Rho and its effector Rho kinase, also known as ROK or ROCK, emerged as key …
particular Rho and its effector Rho kinase, also known as ROK or ROCK, emerged as key …
The role of phosphoinositide 3-kinase C2α in insulin signaling
The members of the class II phosphoinositide 3-kinase (PI3K) family can be activated by
several stimuli, indicating that these enzymes can regulate many intracellular processes …
several stimuli, indicating that these enzymes can regulate many intracellular processes …
Role of myosin light chain kinase and myosin light chain phosphatase in the resistance arterial myogenic response to intravascular pressure
WC Cole, DG Welsh - Archives of biochemistry and biophysics, 2011 - Elsevier
The intrinsic ability of vascular smooth muscle cells (VSMCs) within arterial resistance
vessels to respectively contract and relax in response to elevation and reduction of …
vessels to respectively contract and relax in response to elevation and reduction of …
Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension
M Oka, KA Fagan, PL Jones… - British journal of …, 2008 - Wiley Online Library
A burgeoning body of evidence suggests that RhoA/Rho kinase (ROCK) signalling plays an
important role in the pathogenesis of various experimental models of pulmonary …
important role in the pathogenesis of various experimental models of pulmonary …
Current topics in the regulatory mechanism underlying the Ca2+ sensitization of the contractile apparatus in vascular smooth muscle
K Hirano - Journal of pharmacological sciences, 2007 - Elsevier
The Ca 2+ signal is the primary determinant of the contraction of the vascular smooth
muscle. However, the alteration of the Ca 2+ sensitivity of the contractile apparatus also …
muscle. However, the alteration of the Ca 2+ sensitivity of the contractile apparatus also …