Although diabetes is recognized as a potent and prevalent risk factor for ischemic heart
disease, less is known as to whether diabetes causes an altered cardiac phenotype …

Many investigations suggest the pivotal role of sphingolipids in the pathogenesis of lifestyle
diseases such as myocardial infarction, hypertension, stroke, diabetes mellitus type 2 and …

Activation of cells by receptor-and nonreceptor-mediated stimuli not only requires a change
in the activity of signaling proteins but also requires a reorganization of the topology of the …

Sphingolipids are bioactive lipids found in cell membranes that exert a critical role in signal
transduction. In recent years, it has become apparent that sphingolipids participate in …

Sphingolipids are a structural component of the cell membrane, derived from sphingosine,
an amino alcohol. Its sphingoid base undergoes various types of enzymatic transformations …

Plasma sphingomyelin concentration is correlated with the development of atherosclerosis.
It has been found to exist in significantly higher concentrations in aortic plaque. This appears …

Simple bioactive sphingolipids include ceramide, sphingosine and their phosphorylated
forms sphingosine 1-phosphate and ceramide 1-phosphate. These molecules are crucial …

We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide
predictive of major adverse cardiovascular events in patients with acute myocardial …

Inflammasomes play a critical role in the development of vascular diseases. However, the
molecular mechanisms activating the inflammasome in endothelial cells and the relevance …

Diabetes mellitus (DM) is a major cause of heart failure in the Western world, either
secondary to coronary artery disease or from a distinct entity known as “diabetic …