Liver sinusoidal endothelial cells (LSECs) line the low shear, sinusoidal capillary channels
of the liver and are the most abundant non-parenchymal hepatic cell population. LSECs do …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Ionizable lipid nanoparticles (LNPs) have been widely used for in vivo delivery of RNA
therapeutics into the liver. However, a main challenge remains to develop LNP formulations …

Lipid nanoparticles (LNPs) are the leading nonviral technologies for the delivery of
exogenous RNA to target cells in vivo. As systemic delivery platforms, these technologies …

The accumulation of senescent cells can drive many age-associated phenotypes and
pathologies. Consequently, it has been proposed that removing senescent cells might …

The aim of this review is to give an outline of the blood clearance function of the liver
sinusoidal endothelial cells (LSECs) in health and disease. Lining the hundreds of millions …

Liver sinusoidal endothelial cells (LSEC) form a unique barrier between the liver sinusoids
and the underlying parenchyma, and thus play a crucial role in maintaining metabolic and …

BACKGROUND & AIMS: Capillarization, characterized by loss of differentiation of liver
sinusoidal endothelial cells (LSECs), precedes the onset of hepatic fibrosis. We investigated …

Necrosis is an overarching term that describes cell death modalities caused by (extreme)
adverse conditions in which cells lose structural integrity. A guaranteed consequence of …

Liver sinusoidal endothelial cells (LSECs) are the most abundant non-parenchymal cells
lining the sinusoidal capillaries of the hepatic system. LSECs are characterized with …