The growth hormone receptor: mechanism of activation and clinical implications
Growth hormone is widely used clinically to promote growth and anabolism and for other
purposes. Its actions are mediated via the growth hormone receptor, both directly by tyrosine …
purposes. Its actions are mediated via the growth hormone receptor, both directly by tyrosine …
Targeting growth hormone function: strategies and therapeutic applications
M Lu, JU Flanagan, RJ Langley, MP Hay… - Signal transduction and …, 2019 - nature.com
Human growth hormone (GH) is a classical pituitary endocrine hormone that is essential for
normal postnatal growth and has pleiotropic effects across multiple physiological systems …
normal postnatal growth and has pleiotropic effects across multiple physiological systems …
Growth hormone and reproduction: a review of endocrine and autocrine/paracrine interactions
KL Hull, S Harvey - International journal of endocrinology, 2014 - Wiley Online Library
The somatotropic axis, consisting of growth hormone (GH), hepatic insulin‐like growth factor
I (IGF‐I), and assorted releasing factors, regulates growth and body composition …
I (IGF‐I), and assorted releasing factors, regulates growth and body composition …
Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models
DE Berryman, JS Christiansen, G Johannsson… - Growth Hormone & IGF …, 2008 - Elsevier
Animal models are fundamentally important in our quest to understand the genetic,
epigenetic, and environmental factors that contribute to human aging. In comparison to …
epigenetic, and environmental factors that contribute to human aging. In comparison to …
Peptide hormone regulation of angiogenesis
It is now apparent that regulation of blood vessel growth contributes to the classical actions
of hormones on development, growth, and reproduction. Endothelial cells are ideally …
of hormones on development, growth, and reproduction. Endothelial cells are ideally …
Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions
Adult female mammary development starts at puberty and is controlled by tightly regulated
cross-talk between a group of hormones and growth factors. Although estrogen is the initial …
cross-talk between a group of hormones and growth factors. Although estrogen is the initial …
Role of growth hormone in breast cancer
Breast cancer is one of the most common cancers diagnosed in women. Approximately two-
thirds of all breast cancers diagnosed are classified as hormone dependent, which indicates …
thirds of all breast cancers diagnosed are classified as hormone dependent, which indicates …
Extrapituitary growth hormone
S Harvey - Endocrine, 2010 - Springer
Pituitary somatotrophs secrete growth hormone (GH) into the bloodstream, to act as a
hormone at receptor sites in most, if not all, tissues. These endocrine actions of circulating …
hormone at receptor sites in most, if not all, tissues. These endocrine actions of circulating …
Autocrine/paracrine human growth hormone-stimulated MicroRNA 96-182-183 cluster promotes epithelial-mesenchymal transition and invasion in breast cancer
Human growth hormone (hGH) plays critical roles in pubertal mammary gland growth,
development, and sexual maturation. Accumulated studies have reported that …
development, and sexual maturation. Accumulated studies have reported that …
The use and abuse of growth hormone in sports
GH is banned by the World Anti-Doping Agency as a performance-enhancing anabolic
agent. Doping with GH likely began in the early 1980s and became more prevalent with the …
agent. Doping with GH likely began in the early 1980s and became more prevalent with the …