The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

The release of insulin from pancreatic islets requires negative regulation to ensure low
levels of insulin release under resting conditions, as well as positive regulation to facilitate …

Gestational Diabetes Mellitus (GDM) is defined as glucose intolerance that develops in the
second or third trimester of pregnancy. GDM can lead to short-term and long-term …

Diabetes is a global public health burden and is characterized clinically by relative or
absolute insulin deficiency. Therapeutic agents that stimulate insulin secretion and improve …

The maintenance of whole-body glucose homeostasis is critical for survival, and is
controlled by the coordination of multiple organs and endocrine systems. Pancreatic islet β …

Gestational diabetes mellitus (GDM) is characterized by insulin resistance accompanied by
low/absent beta-cell compensatory adaptation to the increased insulin demand. Although …

Aims/hypothesis Activation of the G protein-coupled receptor (GPR) 40 by long-chain fatty
acids potentiates glucose-stimulated insulin secretion (GSIS) from pancreatic beta cells, and …

Harnessing the translational potential of the GLP-1/GLP-1R system in pancreatic beta cells
has led to the development of established GLP-1R-based therapies for the long-term …

EndoC-βH1 is emerging as a critical human β cell model to study the genetic and
environmental etiologies of β cell (dys) function and diabetes. Comprehensive knowledge of …

Glioblastoma (GB) is the most malignant of primary adult brain tumors, characterized by a
highly locally invasive cell population, as well as abundant proliferative cells …