The human epidermal growth factor receptor (EGFR) family consists of four members that
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …

In the last several decades, there have been significant advances in anticancer therapy.
However, the development of resistance to cancer drugs and the lack of specificity related to …

Background Galunisertib is the first-in-class, first-in-human, oral small-molecule type I
transforming growth factor-beta receptor (ALK5) serine/threonine kinase inhibitor to enter …

Altered expression of secreted factors by tumor cells or cells of the tumor microenvironment
is a key event in cancer development and progression. In the last decade, emerging …

Background Pancreatic adenocarcinoma (PAAD) is one of the most common malignant
tumors of the digestive tract. Pyroptosis is a newly discovered programmed cell death that …

Pancreatic cancer (PC) is the third leading cause of adult cancer mortality in the United
States. The poor prognosis for patients with PC is mainly due to its aggressive course, the …

Mutations of the proto-oncogene KRAS are the most frequent gain-of-function alterations
found in cancer. KRAS is mutated in about 30% of all human tumors, but it could reach more …

The complicated capillary network induced by angiogenesis is one of the main reasons of
unsuccessful cancer therapy. A multi-scale mathematical method which simulates drug …

Cancer, a growing health problem worldwide, affects millions of people every year. The
overall survival rates of most cancers have been prolonged owing to the efforts of clinicians …

The aim of the present study was to examine the efficacy of tumor-targeting Salmonella
typhimurium A1-R treatment following anti-vascular endothelial growth factor (VEGF) …