Nature achieves differentiation of specific and nonspecific binding in molecular interactions
through precise control of biomolecules in space and time. Artificial systems such as …

All soluble proteins populate conformational ensembles that together constitute the native
state. Their fluctuations in water are intrinsic thermodynamic phenomena, and the …

Interactions within a protein structure and interactions between proteins in an assembly are
essential considerations in understanding molecular basis of stability and functions of …

With currently more than 126 000 publicly available structures and an increasing growth
rate, the Protein Data Bank constitutes a rich data source for structure-driven research in …

Proteins are the working horse of the cellular machinery. They are responsible for diverse
functions ranging from molecular motors to signaling. They catalyze reactions, transport …

Transient complexes are crucial for diverse biological processes such as biochemical
pathways and signaling cascades in the cell. Here, we give an overview of the transient …

Motivation: The increasing amount of data on protein–protein interaction needs to be
rationalized for deriving guidelines for the alteration or design of an interface between two …

Background Structural models determined by X-ray crystallography play a central role in
understanding protein-protein interactions at the molecular level. Interpretation of these …

The unanimous agreement that cellular processes are (largely) governed by interactions
between proteins has led to enormous community efforts culminating in overwhelming …

Communication within and across proteins is crucial for the biological functioning of
proteins. Experiments such as mutational studies on proteins provide important information …