Over the past two decades, compelling evidence has emerged indicating that immune
mechanisms can contribute to the pathogenesis of major depressive disorder (MDD) and …

Anhedonia—the loss of pleasure or lack of reactivity to pleasurable stimuli—remains a
formidable treatment challenge across neuropsychiatric disorders. In major depressive …

Objective: Determine whether a novel psychosocial treatment for positive affect improves
clinical status and reward sensitivity more than a form of cognitive behavioral therapy that …

The Hierarchical Taxonomy of Psychopathology (HiTOP) has emerged out of the
quantitative approach to psychiatric nosology. This approach identifies psychopathology …

Major depressive disorder is a leading cause of disability worldwide. Because conventional
therapies are ineffective in many patients, novel strategies are needed to overcome …

Psychiatric disorders associated with psychological trauma, stress and anxiety are a highly
prevalent and increasing cause of morbidity worldwide. Current therapeutic approaches …

The inability to experience pleasure or interest in activities (commonly referred to in clinical
settings as anhedonia) is characteristic of depression, anxiety, post-traumatic stress disorder …

Alcohol addiction is a chronic relapsing brain disease characterized by an impaired ability to
stop or control alcohol use despite adverse consequences. A main challenge of addiction …

This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Alternatives to traditional categorical diagnoses have been proposed to improve the validity
and utility of psychiatric nosology. This paper continues the companion review of an …