Anticancer potential of lichens' secondary metabolites

Z Solárová, A Liskova, M Samec, P Kubatka… - Biomolecules, 2020 - mdpi.com
Lichens produce different classes of phenolic compounds, including anthraquinones,
xanthones, dibenzofuranes, depsides and depsidones. Many of them have revealed …

Enantioselective activity of usnic acid: A comprehensive review and future perspectives

A Galanty, P Paśko, I Podolak - Phytochemistry Reviews, 2019 - Springer
This review is focused on the comparison of the biological and pharmacological activities of
usnic acid enantiomers. Most of the available data refer to (+)-usnic acid, while the left …

Antioxidant and antidiabetic activity and phytoconstituents of lichen extracts with temperate and polar distribution

A Torres-Benítez, JE Ortega-Valencia… - Frontiers in …, 2023 - frontiersin.org
The objective of this research was to characterize the chemical composition of ethanolic
extracts of the lichen species Placopsis contortuplicata, Ochrolechia frigida, and Umbilicaria …

Bioactive lichen secondary metabolites and their presence in species from Chile

E Poulsen-Silva, F Gordillo-Fuenzalida, C Atala… - Metabolites, 2023 - mdpi.com
Lichens are symbiotic organisms composed of at least one fungal and one algal species.
They are found in different environments around the world, even in the poles and deserts …

Lichen depsides and tridepsides: progress in pharmacological approaches

I Ureña-Vacas, E González-Burgos, PK Divakar… - Journal of Fungi, 2023 - mdpi.com
Depsides and tridepsides are secondary metabolites found in lichens. In the last 10 years,
there has been a growing interest in the pharmacological activity of these compounds. This …

Diffractaic acid, a novel TrxR1 inhibitor, induces cytotoxicity, apoptosis, and antimigration in human breast cancer cells

ŞN Kalın, A Altay, H Budak - Chemico-Biological Interactions, 2022 - Elsevier
Breast cancer represents one of the most frequently encountered cancer types among
women worldwide. Thioredoxin reductase 1 (TrxR1) is a therapeutic target for breast cancer …

Neuroprotective effects of boron nitride nanoparticles in the experimental Parkinson's disease model against MPP+ induced apoptosis

R Küçükdoğru, H Türkez, ME Arslan, ÖÖ Tozlu… - Metabolic brain …, 2020 - Springer
Parkinson's disease (PD) is one of the most aggressive neurodegenerative diseases and
characterized by the loss of dopamine-sensitive neurons in the substantia nigra region of the …

Lichen-derived diffractaic acid inhibited dengue virus replication in a cell-based system

N Loeanurit, TL Tuong, VK Nguyen, V Vibulakhaophan… - Molecules, 2023 - mdpi.com
Dengue is a mosquito-borne flavivirus that causes 21,000 deaths annually. Depsides and
depsidones of lichens have previously been reported to be antimicrobials. In this study, our …

Lichens as a repository of bioactive compounds: an open window for green therapy against diverse cancers

TUH Dar, SA Dar, SU Islam, ZA Mangral, R Dar… - Seminars in Cancer …, 2022 - Elsevier
Lichens, algae and fungi-based symbiotic associations, are sources of many important
secondary metabolites, such as antibiotics, anti-inflammatory, antioxidants, and anticancer …

miR-185-5p response to usnic acid suppresses proliferation and regulating apoptosis in breast cancer cell by targeting Bcl2

E Değerli, V Torun, D Cansaran-Duman - Biological research, 2020 - Springer
Background Breast cancer is the most common cancer types among women. Recent
researches have focused on determining the efficiency of alternative molecules and miRNAs …