Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …

The endocannabinoid system (ECS) is a widespread neuromodulatory system that plays
important roles in central nervous system development, synaptic plasticity, and the response …

Despite being regarded as a hippie science for decades, cannabinoid research has finally
found its well-deserved position in mainstream neuroscience. A series of groundbreaking …

The discovery of cannabinoid receptors and subsequent identification of their endogenous
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …

The endocannabinoid (eCB) system has attracted attention for its role in various behavioral
and brain functions, and as a therapeutic target in neuropsychiatric disease states, including …

Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key
regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the …

Abstract Changes in synaptic efficacy are thought to be crucial to experience-dependent
modifications of neural function. The diversity of mechanisms underlying these changes is …

Cannabis sativa is one of the oldest herbal plants in the history of medicine. It was used in
various therapeutic applications from pain to epilepsy, but its psychotropic effect has …

The endogenous cannabinoid signalling system, composed of endogenous cannabinoids,
cannabinoid receptors and the enzymes that synthesize and degrade the endogenous …

Chemical signals, or neurotransmitters, represent the fundamental mode for intercellular
communication in the nervous system. 1 The classical model for neurotransmitter action …