The great plasticity of Schwann cells (SCs), the myelinating glia of the peripheral nervous
system (PNS), is a critical feature in the context of peripheral nerve regeneration following …

The glial cell of the peripheral nervous system (PNS), the Schwann cell (SC), counts among
the most multifaceted cells of the body. During development, SCs secure neuronal survival …

The remarkable plasticity of Schwann cells allows them to adopt the Remak (non-myelin)
and myelin phenotypes, which are specialized to meet the needs of small and large …

Nerve injury triggers the conversion of myelin and non‐myelin (Remak) Schwann cells to a
cell phenotype specialized to promote repair. Distal to damage, these repair Schwann cells …

Schwann cells respond to nerve injury by cellular reprogramming that generates cells
specialized for promoting regeneration and repair. These repair cells clear redundant …

Autophagy is emerging as a core regulator of Central Nervous System (CNS) aging and
neurodegeneration. In the brain, it has mostly been studied in neurons, where the delivery of …

Although Schwann cell myelin breakdown is the universal outcome of a remarkably wide
range of conditions that cause disease or injury to peripheral nerves, the cellular and …

Abstract Rationale: Autophagy in Schwann cells (SCs) is crucial for myelin debris
degradation and clearance following peripheral nerve injury (PNI). Nerve growth factor …

The Rho family of GTPases belongs to the Ras superfamily of low molecular weight (∼ 21
kDa) guanine nucleotide binding proteins. The most extensively studied members are RhoA …

Peripheral nerves exist in a stable state in adulthood providing a rapid bidirectional
signaling system to control tissue structure and function. However, following injury …